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Temporo-cerebellar connectivity underlies timing constraints in audition
- Source :
- eLife, eLife, Vol 10 (2021), Elife, 10:e67303. eLife Sciences Publications, Ltd
- Publication Year :
- 2021
-
Abstract
- The flexible and efficient adaptation to dynamic, rapid changes in the auditory environment likely involves generating and updating of internal models. Such models arguably exploit connections between the neocortex and the cerebellum, supporting proactive adaptation. Here we test the functional mechanisms associated with temporo-cerebellar connectivity, verifying these mechanisms for speech sounds. First, we identify lesion-specific deficits for the encoding of short timescale spectro-temporal non-speech and speech properties in patients with left posterior temporal cortex stroke. Second, using lesion-guided probabilistic tractography in healthy participants, we reveal bidirectional temporo-cerebellar connectivity with cerebellar dentate nuclei and crura I/II. These findings imply that the encoding and modeling of rapidly modulated auditory spectro-temporal properties engage a temporo-cerebellar interface. The data further support the conjecture that proactive adaptation to a dynamic environment via internal models is a generalizable principle.Significance StatementAsymmetric sampling in time, the principle of duration-sensitive hemispheric specialization of the cerebral cortex in the sensory decomposition of sound, is a widely tested hypothesis in auditory neuroscience. This functional organization is mirrored in the cerebellar cortex, implicated in the internal forward-modeling of sensory feedback that arises from motor actions. The potential structural and functional integration of these systems is not well understood. Using a unique combination of causal lesion-symptom mapping in persons with temporal lobe damage and diffusion-weighted magnetic resonance neuroimaging in healthy persons, we identify one key missing link and provide evidence for cross-lateral temporo-cerebellar connectivity using probabilistic white matter fiber tractography. These cerebellar-pontine-temporal cortex connections not only support asymmetric sampling in time but also establish the basis for a generalizable role of cerebellar forward-modeling in sensation beyond the monitoring of sensory feedback in the motor domain.
- Subjects :
- Male
MIDDLE LONGITUDINAL FASCICLE
Cerebellum
Computer science
Interface (computing)
tractography
Left posterior
Task Performance and Analysis
Biology (General)
IN-VIVO
Temporal cortex
Neocortex
General Neuroscience
lesion mapping
Brain
General Medicine
SPEECH
Middle Aged
Magnetic Resonance Imaging
Temporal Lobe
Stroke
medicine.anatomical_structure
Auditory Perception
Medicine
Female
Disconnection
MOTOR
WHITE-MATTER
Research Article
Tractography
Human
Adult
QH301-705.5
Science
audition
General Biochemistry, Genetics and Molecular Biology
Lateralization of brain function
Time
internal models
Encoding (memory)
Connectome
medicine
Humans
lateralization
Adaptation (computer science)
PERCEPTION
General Immunology and Microbiology
RHESUS-MONKEY
temporo-cerebellar connectivity
nervous system
Case-Control Studies
PROJECTIONS
Neuroscience
SYSTEM
Subjects
Details
- Language :
- English
- ISSN :
- 2050084X
- Database :
- OpenAIRE
- Journal :
- eLife, eLife, Vol 10 (2021), Elife, 10:e67303. eLife Sciences Publications, Ltd
- Accession number :
- edsair.doi.dedup.....4358043a9dcb07456bf7fc615273ab3d