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The Position of Inhaled Chemotherapy in the Care of Patients with Lung Tumors: Clinical Feasibility and Indications According to Recent Pharmaceutical Progresses
- Source :
- Cancers, Cancers, 11 (329, Cancers, Vol 11, Iss 3, p 329 (2019), Cancers (Basel), 11 (3
- Publication Year :
- 2019
- Publisher :
- MDPI, 2019.
-
Abstract
- Despite new treatment modalities, including targeted therapies and checkpoint inhibitors, cytotoxic chemotherapy remains central in the care of patients with lung tumors. Use of the pulmonary route to deliver chemotherapy has been proved to be feasible and safe in phase I, Ib/IIa and II trials for lung tumors, with the administration of drug doses to the lungs without prior distribution in the organism. The severe systemic toxicities commonly observed with conventional systemic chemotherapy are consequently reduced. However, development has failed in phase II at best. This review first focuses on the causes of failure of inhaled chemotherapy. It then presents new promising technologies able to take up the current challenges. These technologies include the use of a dry powder inhaler or a smart nebulizer with advanced drug formulations such as controlled-release formulations and nanomedicine. Finally, the potential position of inhaled chemotherapy in patient care is discussed and some indications are proposed based on the literature.<br />SCOPUS: re.j<br />info:eu-repo/semantics/published
- Subjects :
- Cancer Research
Drug doses
medicine.medical_specialty
Lung cancer chemotherapy
medicine.medical_treatment
pulmonary delivery
02 engineering and technology
Review
Metastases
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
Non-small cell lung cancer
medicine
In patient
Pulmonary delivery
Intensive care medicine
metastases
non-small cell lung cancer
Chemotherapy
Lung
Systemic chemotherapy
business.industry
Sciences bio-médicales et agricoles
Cytotoxic chemotherapy
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
021001 nanoscience & nanotechnology
Dry-powder inhaler
Cancérologie
Nebulizer
lung cancer chemotherapy
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
0210 nano-technology
business
Subjects
Details
- Language :
- English
- ISSN :
- 20726694
- Volume :
- 11
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Cancers
- Accession number :
- edsair.doi.dedup.....43688231c88a0de8a166624d01dcb8ef