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Burden of illness of the 2009 pandemic of influenza A (H1N1) in Denmark
- Source :
- Vaccine. 29
- Publication Year :
- 2010
-
Abstract
- We analysed Danish surveillance data to estimate influenza-associated morbidity and mortality in 2009. To obtain population-based estimates of the clinical attack rate, we combined data from two different primary health care surveillance systems, national numbers of the proportion of positive influenza tests, and data from a web-based interview on health care seeking behaviour during the pandemic. From a national registry, we obtained data on hospital admissions (ICD-10 codes) for influenza related conditions. Admission to intensive care was monitored by a dedicated surveillance scheme. Mortality was estimated among laboratory confirmed cases but was also expressed as excess all-cause mortality attributed to influenza-like illness in a multivariable time series analysis. In total, we estimated that 274,000 individuals (5%) in Denmark experienced clinical illness. The highest attack rate was found in children 5–14 years (15%). Compared with the expected number of hospital admissions, there was an 80% increase in number of influenza related hospital admissions in this age group. The numbers of patients admitted to intensive care approached 5% of the national capacity. Estimates of the number of deaths ranged from 30 to 312 (0.5–5.7 per 100,000 population) depending on the methodology. In conclusion, the pandemic was characterised by high morbidity and unprecedented high rates of admissions to hospitals for a range of influenza-related conditions affecting mainly children. Nonetheless, the burden of illness was lower than assumed in planning scenarios, and the present pandemic compares favourable with the 20th century pandemics.
- Subjects :
- Adult
Male
Pediatrics
medicine.medical_specialty
Adolescent
Denmark
Attack rate
Population
MEDLINE
medicine.disease_cause
Danish
Young Adult
Age Distribution
Influenza A Virus, H1N1 Subtype
Cost of Illness
Intensive care
Pandemic
Influenza, Human
medicine
Influenza A virus
Humans
Young adult
education
Child
Pandemics
Aged
education.field_of_study
General Veterinary
General Immunology and Microbiology
business.industry
Public Health, Environmental and Occupational Health
Infant
Middle Aged
language.human_language
Hospitalization
Infectious Diseases
Child, Preschool
language
Molecular Medicine
Female
Seasons
business
Demography
Subjects
Details
- ISSN :
- 18732518
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Vaccine
- Accession number :
- edsair.doi.dedup.....4379f9c8b7e5d0338417d13ee41a04b6