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Enrichment of CCR6+ CD8+ T cells and CCL20 in the lungs of mechanically ventilated patients with COVID-19
- Source :
- Saris, A, Reijnders, T D Y, Reijm, M, Hollander, J C, de Buck, K, Schuurman, A R, Duitman, J, Heunks, L, Aman, J, Bogaard, H J, Nossent, E J, van der Poll, T, Bontkes, H J & Amsterdam UMC COVID study group 2021, ' Enrichment of CCR6+ CD8+ T cells and CCL20 in the lungs of mechanically ventilated patients with COVID-19 ', European Journal of Immunology, vol. 51, no. 6, pp. 1535-1538 . https://doi.org/10.1002/eji.202049046, European Journal of Immunology, 51(6), 1535-1538. Wiley-VCH Verlag, European journal of immunology, 51(6), 1535-1538. Wiley-VCH Verlag
- Publication Year :
- 2021
-
Abstract
- Despite high levels of CXCR3 ligands in mechanically ventilated COVID-19 patients, BALF CD8 T cells were not enriched in CXCR3+ cells but rather CCR6+ , likely due to high CCL20 levels in BALF, and had very high PD-1 expression. In mechanically ventilated, but not ward, patients Th-1 immunity is impaired. .
- Subjects :
- 0301 basic medicine
2019-20 coronavirus outbreak
Coronavirus disease 2019 (COVID-19)
animal diseases
Immunology
T cells
chemical and pharmacologic phenomena
C-C chemokine receptor type 6
Biology
CXCR3
Microbiology
03 medical and health sciences
0302 clinical medicine
Immunity
medicine
Immunology and Allergy
Cytotoxic T cell
Lung
COVID-19
hemic and immune systems
respiratory system
respiratory tract diseases
CCL20
030104 developmental biology
medicine.anatomical_structure
CCR6
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 00142980
- Database :
- OpenAIRE
- Journal :
- Saris, A, Reijnders, T D Y, Reijm, M, Hollander, J C, de Buck, K, Schuurman, A R, Duitman, J, Heunks, L, Aman, J, Bogaard, H J, Nossent, E J, van der Poll, T, Bontkes, H J & Amsterdam UMC COVID study group 2021, ' Enrichment of CCR6+ CD8+ T cells and CCL20 in the lungs of mechanically ventilated patients with COVID-19 ', European Journal of Immunology, vol. 51, no. 6, pp. 1535-1538 . https://doi.org/10.1002/eji.202049046, European Journal of Immunology, 51(6), 1535-1538. Wiley-VCH Verlag, European journal of immunology, 51(6), 1535-1538. Wiley-VCH Verlag
- Accession number :
- edsair.doi.dedup.....43bfa00c614a98bd18d423d5a0bdf2d1
- Full Text :
- https://doi.org/10.1002/eji.202049046