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Circulating Tumor DNA-Based Disease Monitoring of Patients with Locally Advanced Esophageal Cancer
- Source :
- Cancers, 14, Cancers; Volume 14; Issue 18; Pages: 4417, Cancers, 14, 18
- Publication Year :
- 2022
-
Abstract
- Patients diagnosed with locally advanced esophageal cancer are often treated with neoadjuvant chemoradiotherapy followed by surgery. This study explored whether detection of circulating tumor DNA (ctDNA) in plasma can be used to predict residual disease during treatment. Diagnostic tissue biopsies from patients with esophageal cancer receiving neoadjuvant chemoradiotherapy and surgery were analyzed for tumor-specific mutations. These tumor-informed mutations were used to measure the presence of ctDNA in serially collected plasma samples using hybrid capture-based sequencing. Plasma samples were obtained before chemoradiotherapy, and prior to surgery. The association between ctDNA detection and progression-free and overall survival was measured. Before chemoradiotherapy, ctDNA was detected in 56% (44/78) of patients and detection was associated with tumor stage and volume (p = 0.05, Fisher exact and p = 0.02, Mann-Whitney, respectively). After chemoradiotherapy, ctDNA was detected in 10% (8/78) of patients. This preoperative detection of ctDNA was independently associated with recurrent disease (hazard ratio 2.8, 95% confidence interval 1.1–6.8, p = 0.03, multivariable Cox-regression) and worse overall survival (hazard ratio 2.9, 95% confidence interval 1.2–7.1, p = 0.02, multivariable Cox-regression).Ultradeep sequencing-based detection of ctDNA in preoperative plasma of patients with locally advanced esophageal cancer may help to assess which patients have a high risk of recurrence after neoadjuvant chemoradiotherapy and surgery.
- Subjects :
- Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14]
Cancer Research
All institutes and research themes of the Radboud University Medical Center
Oncology
Urological cancers Radboud Institute for Health Sciences [Radboudumc 15]
Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2]
Other Research Radboud Institute for Health Sciences [Radboudumc 0]
Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14]
esophageal cancer
circulating tumor DNA
neoadjuvant treatment
liquid biopsies
next-generation sequencing
Metabolic Disorders Radboud Institute for Molecular Life Sciences [Radboudumc 6]
Subjects
Details
- ISSN :
- 20726694
- Database :
- OpenAIRE
- Journal :
- Cancers, 14, Cancers; Volume 14; Issue 18; Pages: 4417, Cancers, 14, 18
- Accession number :
- edsair.doi.dedup.....43d0951fa2deab019cf5e5d32be1178f