Back to Search Start Over

Circulating Tumor DNA-Based Disease Monitoring of Patients with Locally Advanced Esophageal Cancer

Authors :
Lisa S. M. Hofste
Maartje J. Geerlings
Daniel von Rhein
Sofie H. Tolmeijer
Marjan M. Weiss
Christian Gilissen
Tom Hofste
Linda M. Garms
Marcel J. R. Janssen
Heidi Rütten
Camiel Rosman
Rachel S. van der Post
Bastiaan R. Klarenbeek
Marjolijn J. L. Ligtenberg
Source :
Cancers, 14, Cancers; Volume 14; Issue 18; Pages: 4417, Cancers, 14, 18
Publication Year :
2022

Abstract

Patients diagnosed with locally advanced esophageal cancer are often treated with neoadjuvant chemoradiotherapy followed by surgery. This study explored whether detection of circulating tumor DNA (ctDNA) in plasma can be used to predict residual disease during treatment. Diagnostic tissue biopsies from patients with esophageal cancer receiving neoadjuvant chemoradiotherapy and surgery were analyzed for tumor-specific mutations. These tumor-informed mutations were used to measure the presence of ctDNA in serially collected plasma samples using hybrid capture-based sequencing. Plasma samples were obtained before chemoradiotherapy, and prior to surgery. The association between ctDNA detection and progression-free and overall survival was measured. Before chemoradiotherapy, ctDNA was detected in 56% (44/78) of patients and detection was associated with tumor stage and volume (p = 0.05, Fisher exact and p = 0.02, Mann-Whitney, respectively). After chemoradiotherapy, ctDNA was detected in 10% (8/78) of patients. This preoperative detection of ctDNA was independently associated with recurrent disease (hazard ratio 2.8, 95% confidence interval 1.1–6.8, p = 0.03, multivariable Cox-regression) and worse overall survival (hazard ratio 2.9, 95% confidence interval 1.2–7.1, p = 0.02, multivariable Cox-regression).Ultradeep sequencing-based detection of ctDNA in preoperative plasma of patients with locally advanced esophageal cancer may help to assess which patients have a high risk of recurrence after neoadjuvant chemoradiotherapy and surgery.

Details

ISSN :
20726694
Database :
OpenAIRE
Journal :
Cancers, 14, Cancers; Volume 14; Issue 18; Pages: 4417, Cancers, 14, 18
Accession number :
edsair.doi.dedup.....43d0951fa2deab019cf5e5d32be1178f