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Effects of Vitamin D Receptor Activation and Dietary Sodium Restriction on Residual Albuminuria in CKD: The ViRTUE-CKD Trial
- Source :
- Journal of the American Society of Nephrology, 28(4), 1296-1305. AMER SOC NEPHROLOGY, Journal of the American Society of Nephrology, 28(4), 1296-1305. American Society of Nephrology, Keyzer, C A, van Breda, G F, Vervloet, M G, de Jong, M A, Laverman, G D, Hemmelder, M H, Janssen, W M T, Lambers Heerspink, H J, Kwakernaak, A J, Bakker, S J L, Navis, G, de Borst, M H & Holland Nephrology Study (HONEST) Network 2017, ' Effects of Vitamin D Receptor Activation and Dietary Sodium Restriction on Residual Albuminuria in CKD : The ViRTUE-CKD Trial ', Journal of the American Society of Nephrology, vol. 28, no. 4, pp. 1296-1305 . https://doi.org/10.1681/ASN.2016040407
- Publication Year :
- 2017
-
Abstract
- Reduction of residual albuminuria during single-agent renin-angiotensin-aldosterone blockade is accompanied by improved cardiorenal outcomes in CKD. We studied the individual and combined effects of the vitamin D receptor activator paricalcitol (PARI) and dietary sodium restriction on residual albuminuria in CKD. In a multicenter, randomized, placebo (PLAC)-controlled, crossover trial, 45 patients with nondiabetic CKD stages 1-3 and albuminuria >300 mg/24 h despite ramipril at 10 mg/d and BP
- Subjects :
- Paricalcitol
Ramipril
CHRONIC KIDNEY-DISEASE
medicine.medical_specialty
030232 urology & nephrology
Renal function
RENAL-INSUFFICIENCY
BLOOD-PRESSURE
030204 cardiovascular system & hematology
Placebo
GLOMERULAR-FILTRATION-RATE
DIABETIC-NEPHROPATHY
Diabetic nephropathy
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
1,25-DIHYDROXYVITAMIN D-3
business.industry
General Medicine
RANDOMIZED CONTROLLED-TRIAL
medicine.disease
Crossover study
Confidence interval
COMBINATION THERAPY
Endocrinology
RENIN-ANGIOTENSIN SYSTEM
Nephrology
25-DIHYDROXYVITAMIN D-3
Albuminuria
medicine.symptom
business
CONVERTING-ENZYME-INHIBITOR
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 10466673
- Database :
- OpenAIRE
- Journal :
- Journal of the American Society of Nephrology, 28(4), 1296-1305. AMER SOC NEPHROLOGY, Journal of the American Society of Nephrology, 28(4), 1296-1305. American Society of Nephrology, Keyzer, C A, van Breda, G F, Vervloet, M G, de Jong, M A, Laverman, G D, Hemmelder, M H, Janssen, W M T, Lambers Heerspink, H J, Kwakernaak, A J, Bakker, S J L, Navis, G, de Borst, M H & Holland Nephrology Study (HONEST) Network 2017, ' Effects of Vitamin D Receptor Activation and Dietary Sodium Restriction on Residual Albuminuria in CKD : The ViRTUE-CKD Trial ', Journal of the American Society of Nephrology, vol. 28, no. 4, pp. 1296-1305 . https://doi.org/10.1681/ASN.2016040407
- Accession number :
- edsair.doi.dedup.....43e18413bd8128044542e3c5bf00085f
- Full Text :
- https://doi.org/10.1681/ASN.2016040407