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Dietary guidance and ileal enteroendocrine cells in patients with irritable bowel syndrome
- Source :
- Experimental and Therapeutic Medicine
- Publication Year :
- 2016
- Publisher :
- D.A. Spandidos, 2016.
-
Abstract
- The enteroendocrine cells of the ileum are stimulated by the luminal contents to release specific hormones that regulate its functions. The density of ileal enteroendocrine cells is abnormal in patients with irritable bowel syndrome (IBS), and the majority of patients with IBS associate their symptoms to the consumption of certain foodstuffs. The present study investigated the effect of dietary guidance on the enteroendocrine cells of the ileum in 11 patients with IBS. A total of 10 control subjects were also included. Each patient received three sessions of dietary guidance. Colonoscopies were performed on both controls and patients with IBS (at baseline and 3-9 months after the patients had received dietary guidance). Biopsy samples from the ileum were immunostained for all enteroendocrine cells and quantified by computerized image analysis. The densities of serotonin-immunoreactive cells in controls and in patients with IBS prior to and following dietary guidance were 35.5±5.7, 38.7±7.1 and 22.3±2.6 cells/mm2, respectively (mean ± standard error of the mean; P=0.046); the corresponding values for PYY-immunoreactive cells were 16.7±2.8, 20.2±5.1 and 21.3±2.7 cells/mm2 (P=0.86). These results suggest that changes in enteroendocrine cell densities in the ileum along with changes in enteroendocrine cells throughout the gastrointestinal tract may contribute to the improvement in IBS symptoms following dietary guidance.
- Subjects :
- Cancer Research
medicine.medical_specialty
Ileum
Enteroendocrine cell
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Immunology and Microbiology (miscellaneous)
image analysis
Internal medicine
Biopsy
medicine
Irritable bowel syndrome
irritable bowel syndrome
Gastrointestinal tract
medicine.diagnostic_test
enteroendocrine cells
business.industry
General Medicine
Articles
medicine.disease
Molecular medicine
medicine.anatomical_structure
030220 oncology & carcinogenesis
immunohistochemistry
Immunohistochemistry
030211 gastroenterology & hepatology
ileum
business
diet
Hormone
Subjects
Details
- Language :
- English
- ISSN :
- 17921015 and 17920981
- Volume :
- 12
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Experimental and Therapeutic Medicine
- Accession number :
- edsair.doi.dedup.....43e54ed14b694aed5a9f336b1d7ebef3