Back to Search
Start Over
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
- Source :
- Schumacher, F R, Al Olama, A A, Berndt, S I, Benlloch, S, Ahmed, M, Saunders, E J, Dadaev, T, Leongamornlert, D, Anokian, E, Cieza-Borrella, C, Goh, C, Brook, M N, Sheng, X, Fachal, L, Dennis, J, Tyrer, J, Muir, K, Lophatananon, A, Stevens, V L, Gapstur, S M, Carter, B D, Tangen, C M, Goodman, P J, Thompson, I M, Batra, J, Chambers, S, Moya, L, Clements, J, Horvath, L, Tilley, W, Risbridger, G P, Gronberg, H, Aly, M, Nordström, T, Pharoah, P, Pashayan, N, Schleutker, J, Tammela, T L J, Sipeky, C, Auvinen, A, Albanes, D, Weinstein, S, Wolk, A, Sorensen, K D, Orntoft, T F, Borre, M & Profile Study 2018, ' Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci ', Nature Genetics, vol. 50, no. 7, pp. 928-936 . https://doi.org/10.1038/s41588-018-0142-8, the Profile Study 2018, ' Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci ', Nature Genetics, vol. 50, no. 7, 8, pp. 928-936 . https://doi.org/10.1038/s41588-018-0142-8, Nature Genetics, 50(7), 928-+. Nature Publishing Group
- Publication Year :
- 2018
- Publisher :
- Nature Publishing Group, 2018.
-
Abstract
- Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa cases and 27,910 controls of European ancestry with previously genotyped data of 32,255 PrCa cases and 33,202 controls of European ancestry. Our analysis identified 62 novel loci associated (P < 5.0 × 10-8) with PrCa and one locus significantly associated with early-onset PrCa (≤55 years). Our findings include missense variants rs1800057 (odds ratio (OR) = 1.16; P = 8.2 × 10-9; G>C, p.Pro1054Arg) in ATM and rs2066827 (OR = 1.06; P = 2.3 × 10-9; T>G, p.Val109Gly) in CDKN1B. The combination of all loci captured 28.4% of the PrCa familial relative risk, and a polygenic risk score conferred an elevated PrCa risk for men in the ninetieth to ninety-ninth percentiles (relative risk = 2.69; 95% confidence interval (CI): 2.55-2.82) and first percentile (relative risk = 5.71; 95% CI: 5.04-6.48) risk stratum compared with the population average. These findings improve risk prediction, enhance fine-mapping, and provide insight into the underlying biology of PrCa 1 .
- Subjects :
- 0301 basic medicine
Oncology
Male
PREDICTION
Cancer of the Prostate in Sweden (CAPS)
Genome-wide association study
PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium
VARIANTS
Australian Prostate Cancer BioResource (APCB)
urologic and male genital diseases
DISEASE
FAMILY-HISTORY
PATHWAY
Prostate cancer
Prostate Cancer Genome-wide Association Study of Uncommon Susceptibility Loci (PEGASUS)
11 Medical and Health Sciences
Genetics & Heredity
RISK
education.field_of_study
Profile Study
IMPACT Study
3. Good health
prostate cancer (PrCa)-susceptibility loci
Centre for Surgical Research
BIOLOGICAL PATHWAYS
ICEP
Life Sciences & Biomedicine
Medical Genetics
Risk
medicine.medical_specialty
Genotype
Population
Biology
Polymorphism, Single Nucleotide
03 medical and health sciences
MULTIPLE LOCI
Breast and Prostate Cancer Cohort Consortium (BPC3)
SDG 3 - Good Health and Well-being
Internal medicine
Genetic model
Genetics
medicine
Humans
Genetic Predisposition to Disease
GENOME-WIDE ASSOCIATION
education
Genotyping
METAANALYSIS
Medicinsk genetik
Genetic association
Canary PASS Investigators
Science & Technology
IDENTIFICATION
CONSORTIUM
Case-control study
Prostatic Neoplasms
06 Biological Sciences
medicine.disease
GENE
Genetic Associations and Mechanisms in Oncology (GAME-ON)/Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium
030104 developmental biology
Genetic Loci
Relative risk
Case-Control Studies
genotype
humans
male
Developmental Biology
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 15461718 and 10614036
- Volume :
- 50
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Nature Genetics
- Accession number :
- edsair.doi.dedup.....440cb385cd9e0ed608a7b8e0cf8117c2