Back to Search
Start Over
IgD cross-linking induces gene expression profiling changes and enhances apoptosis in chronic lymphocytic leukemia cells
- Source :
- Leukemia Research. 37:455-462
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Gene profile and functional changes upon IgD cross-linking were evaluated in chronic lymphocytic leukemia (CLL). Microarrays highlighted responsiveness to IgD in all cases, independently of clinico-biological characteristics. Stimulated samples exhibited the down-regulation of transcripts of B-cell receptor signaling and cell-adhesion at 24h and the up-modulation of differentiation and apoptosis genes at 48 h. A significant increase in apoptosis upon ligation was also documented. Furthermore, comparison between IgD and IgM stimulation displayed a differential transcriptional/functional response. In conclusion, CLL respond to IgD displaying expression changes and cell-death enhancement, indicating the apoptosis induction via-IgD as an alternative approach for CLL management.
- Subjects :
- Male
Cancer Research
Microarray
Chronic lymphocytic leukemia
B-cell receptor
Apoptosis
chemical and pharmacologic phenomena
Immunoglobulin D
Immunophenotyping
immune system diseases
Cell Line, Tumor
hemic and lymphatic diseases
medicine
Humans
antigenic stimulation
apoptosis
b-cell receptor
cell cycle
cll
microarray
Aged
Oligonucleotide Array Sequence Analysis
biology
Gene Expression Profiling
Cell Cycle
Hematology
Middle Aged
medicine.disease
Leukemia, Lymphocytic, Chronic, B-Cell
Molecular biology
Gene expression profiling
Leukemia
Oncology
biology.protein
Cancer research
Female
Subjects
Details
- ISSN :
- 01452126
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Leukemia Research
- Accession number :
- edsair.doi.dedup.....441c0bbb45112878dc51cc737184a48f
- Full Text :
- https://doi.org/10.1016/j.leukres.2012.12.019