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IgD cross-linking induces gene expression profiling changes and enhances apoptosis in chronic lymphocytic leukemia cells

Authors :
Marilisa Marinelli
Sabina Chiaretti
Francesca Romana Mauro
Simona Santangelo
Simona Tavolaro
Ilaria Del Giudice
Nadia Peragine
Monica Messina
Valeria Di Maio
Anna Guarini
Maria Rosaria Ricciardi
Sara Raponi
Robin Foà
Source :
Leukemia Research. 37:455-462
Publication Year :
2013
Publisher :
Elsevier BV, 2013.

Abstract

Gene profile and functional changes upon IgD cross-linking were evaluated in chronic lymphocytic leukemia (CLL). Microarrays highlighted responsiveness to IgD in all cases, independently of clinico-biological characteristics. Stimulated samples exhibited the down-regulation of transcripts of B-cell receptor signaling and cell-adhesion at 24h and the up-modulation of differentiation and apoptosis genes at 48 h. A significant increase in apoptosis upon ligation was also documented. Furthermore, comparison between IgD and IgM stimulation displayed a differential transcriptional/functional response. In conclusion, CLL respond to IgD displaying expression changes and cell-death enhancement, indicating the apoptosis induction via-IgD as an alternative approach for CLL management.

Details

ISSN :
01452126
Volume :
37
Database :
OpenAIRE
Journal :
Leukemia Research
Accession number :
edsair.doi.dedup.....441c0bbb45112878dc51cc737184a48f
Full Text :
https://doi.org/10.1016/j.leukres.2012.12.019