Additional file 1 of Hippocampal interleukin-33 mediates neuroinflammation-induced cognitive impairments

Additional file 1. The emotional state of mice was tested 24H after the intrahippocampal microinjection. Anxiety-like behavior, representing by the time spent in center of the open field, was not different between: (a) mice intrahippocampal injected with vehicle solution (Veh) versus rmIL-33, (b) mice intrahippocampal injected with vehicle solution versus rmIL-33 treated with minocycline, (c) IL-1αβ KO mice intrahippocampal injected with vehicle solution versus rmIL-33. Values are mean ± SEM, n = 8-15 per group, Mann-Whitney test was used to compare the time spent in the center between 2 groups.