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Natural interferon-beta plus ribavirin therapy led to sustained virological response after seven unsuccessful courses of anti-viral treatment in a chronic hepatitis C patient
- Source :
- Clinical Journal of Gastroenterology. 6:160-163
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- We describe a patient infected with hepatitis C virus (HCV) genotype 1 who failed to respond to interferon with or without ribavirin seven times but who then achieved sustained virological response by the combination of interferon-beta plus ribavirin treatment for 48 weeks. He did not respond to stronger treatment such as prolonged peginterferon plus ribavirin treatment for 87 weeks. It might be rare to treat a patient with interferon 8 times considering the cost and time, since patients failing interferon treatment several times are regarded to be refractory to interferon. It is possible that the difference in biological effects between interferon-alfa and interferon-beta might have resulted in a different outcome in our patient. Interferon-beta plus ribavirin therapy might be one of the treatment options for certain patients chronically infected with HCV who do not respond to standard care treatment.
- Subjects :
- medicine.medical_specialty
Hepatitis C virus
medicine.disease_cause
Gastroenterology
chemistry.chemical_compound
Refractory
Surgical oncology
Interferon
Internal medicine
medicine
Neutralizing antibody
biology
business.industry
Ribavirin
virus diseases
General Medicine
Hepatitis C
Hepatology
medicine.disease
Virology
digestive system diseases
chemistry
biology.protein
business
medicine.drug
Subjects
Details
- ISSN :
- 18657265 and 18657257
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Clinical Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....446b3f413bd0e247a3e0de3d4f7b7a4b