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Oncogenic miR-23a-5p is associated with cellular function in RCC
- Source :
- Molecular Medicine Reports. 16:2309-2317
- Publication Year :
- 2017
- Publisher :
- Spandidos Publications, 2017.
-
Abstract
- In recent years, accumulating evidence has demonstrated that microRNAs (miRs, miRNAs) may serve an important role in the occurrence and development of tumors. miR‑23a‑5p has been confirmed as an oncogene in numerous diseases through gene chip analysis. However, as the most common type of renal tumor, the expression and function of miR‑23a‑5p in renal cell carcinoma (RCC) remains unclear. In the present study, reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) analysis, and Cell Counting Kit‑8 (CCK‑8), wound scratch, Transwell, MTT and flow cytometry assays were performed to investigate the role of miR‑23a‑5p in RCC. The expression of miR‑23a‑5p in RCC tissue samples was significantly higher compared with that in normal tissue samples (P
- Subjects :
- Adult
Male
0301 basic medicine
Cancer Research
Cell Survival
Cell
Down-Regulation
Biology
urologic and male genital diseases
Biochemistry
Flow cytometry
03 medical and health sciences
0302 clinical medicine
Downregulation and upregulation
Cell Movement
Cell Line, Tumor
microRNA
Genetics
medicine
Humans
Carcinoma, Renal Cell
Molecular Biology
Aged
Cell Proliferation
medicine.diagnostic_test
Oncogene
Cell growth
Antagomirs
Middle Aged
Cell cycle
Molecular medicine
Kidney Neoplasms
Up-Regulation
MicroRNAs
HEK293 Cells
030104 developmental biology
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Cancer research
Molecular Medicine
Female
Subjects
Details
- ISSN :
- 17913004 and 17912997
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Molecular Medicine Reports
- Accession number :
- edsair.doi.dedup.....446c5d3514349b7f39b7612cc103e0a0