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Potential Health and Environmental Risks of Three-Dimensional Engineered Polymers
- Source :
- Environmental Science & Technology Letters, Environmental Science & Technology Letters, 2018, 5 (2), pp.80-85. ⟨10.1021/acs.estlett.7b00495⟩, Environmental science & technology letters, 5(2), 80-85. American Chemical Society, Environmental Science and Technology Letters, 5(2), 80, Environmental science & technology letters, 5(2), 80. American Chemical Society
- Publication Year :
- 2018
-
Abstract
- Polymer engineering, such as in three-dimensional (3D) printing, is rapidly gaining popularity, not only in the scientific and medical fields but also in the community in general. However, little is known about the toxicity of engineered materials. Therefore, we assessed the toxicity of 3D-printed and molded parts from five different polymers commonly used for prototyping, fabrication of organ-on-a-chip platforms, and medical devices. Toxic effects of PIC100, E-Shell200, E-Shell300, polydimethylsiloxane, and polystyrene (PS) on early bovine embryo development, on the transactivation of estrogen receptors were assessed, and possible polymer-leached components were identified by mass spectrometry. Embryo development beyond the two-cell stage was inhibited by PIC100, E-Shell200, and E-Shell300 and correlated to the released amount of diethyl phthalate and polyethylene glycol. Furthermore, all polymers (except PS) induced estrogen receptor transactivation. The released materials from PIC100 inhibited embryo cleavage across a confluent monolayer culture of oviduct epithelial cells and also inhibited oocyte maturation. These findings highlight the need for cautious use of engineered polymers for household 3D printing and bioengineering of culture and medical devices and the need for the safe disposal of used devices and associated waste.
- Subjects :
- 0301 basic medicine
Letter
Health, Toxicology and Mutagenesis
UT-Hybrid-D
Estrogen receptor
Polyethylene glycol
010501 environmental sciences
Diethyl phthalate
01 natural sciences
Polymer engineering
03 medical and health sciences
chemistry.chemical_compound
Transactivation
[CHIM]Chemical Sciences
Environmental Chemistry
Toxicology and Mutagenesis
Waste Management and Disposal
ComputingMilieux_MISCELLANEOUS
0105 earth and related environmental sciences
Water Science and Technology
chemistry.chemical_classification
Ecology
Chemistry
Polymer
Pollution
Cell biology
030104 developmental biology
[CHIM.POLY]Chemical Sciences/Polymers
Health
Toxicity
Oviduct
Subjects
Details
- Language :
- English
- ISSN :
- 23288930
- Database :
- OpenAIRE
- Journal :
- Environmental Science & Technology Letters, Environmental Science & Technology Letters, 2018, 5 (2), pp.80-85. ⟨10.1021/acs.estlett.7b00495⟩, Environmental science & technology letters, 5(2), 80-85. American Chemical Society, Environmental Science and Technology Letters, 5(2), 80, Environmental science & technology letters, 5(2), 80. American Chemical Society
- Accession number :
- edsair.doi.dedup.....446dd2228c3a905fcbf231811b24183b