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A NOVEL METHOD TO ESTIMATE LYMPHOCYTE DOSE AND APPLICATION TO PEDIATRIC AND YOUNG ADULT CT PATIENTS IN THE UNITED KINGDOM
- Source :
- Radiation Protection Dosimetry. 178:116-121
- Publication Year :
- 2017
- Publisher :
- Oxford University Press (OUP), 2017.
-
Abstract
- Despite decades of epidemiological research, it remains uncertain whether ionizing radiation can cause lymphomas. Most epidemiological studies of lymphoma risk following non-uniform exposure used dose to red bone marrow (RBM), constituting a small fraction of the lymphocytes, as a surrogate of dose to the lymphocytes. We developed a method to estimate dose to the lymphocytes using the reference distribution of lymphocytes throughout the body and Monte Carlo simulations of computational human phantoms. We applied our method to estimating lymphocyte doses for a pediatric CT patient cohort in the United Kingdom. Estimated dose to the RBM was greater than lymphocyte dose for most scan types (up to 2.6-fold higher, a 5-year-old brain scan) except abdomen scan (RBM dose was about half the lymphocyte dose, a 5-year-old abdomen scan). The lymphocyte dose in the UK cohort showed that T-spine and whole body scans delivered the highest lymphocyte doses (up to 22.4 mGy).
- Subjects :
- Male
Paper
Pathology
medicine.medical_specialty
Adolescent
Lymphocyte
Scan types
Abdomen scan
Radiation Dosage
030218 nuclear medicine & medical imaging
Ionizing radiation
Young Adult
03 medical and health sciences
0302 clinical medicine
Humans
Medicine
Computer Simulation
Radiology, Nuclear Medicine and imaging
Lymphocytes
Young adult
Child
Radiation
Radiological and Ultrasound Technology
Phantoms, Imaging
business.industry
Infant, Newborn
Public Health, Environmental and Occupational Health
Infant
General Medicine
medicine.disease
United Kingdom
Lymphoma
medicine.anatomical_structure
Child, Preschool
030220 oncology & carcinogenesis
Cohort
Female
Tomography, X-Ray Computed
business
Whole body
Nuclear medicine
Monte Carlo Method
Subjects
Details
- ISSN :
- 17423406 and 01448420
- Volume :
- 178
- Database :
- OpenAIRE
- Journal :
- Radiation Protection Dosimetry
- Accession number :
- edsair.doi.dedup.....446ee409022a3dd2ecb20676d96e924e