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Evaluation and characterization of HSPA5 (GRP78) expression profiles in normal individuals and cancer patients with COVID-19
- Source :
- International Journal of Biological Sciences
- Publication Year :
- 2021
- Publisher :
- Ivyspring International Publisher, 2021.
-
Abstract
- HSPA5 (BiP, GRP78) has been reported as a potential host-cell receptor for SARS-Cov-2, but its expression profiles on different tissues including tumors, its susceptibility to SARS-Cov-2 virus and severity of its adverse effects on malignant patients are unclear. In the current study, HSPA5 has been found to be expressed ubiquitously in normal tissues and significantly increased in 14 of 31 types of cancer tissues. In lung cancer, mRNA levels of HSPA5 were 253-fold increase than that of ACE2. Meanwhile, in both malignant tumors and matched normal samples across almost all cancer types, mRNA levels of HSPA5 were much higher than those of ACE2. Higher expression of HSPA5 significantly decreased patient overall survival (OS) in 7 types of cancers. Moreover, systematic analyses found that 7.15% of 5,068 COVID-19 cases have malignant cancer coincidental situations, and the rate of severe events of COVID-19 patients with cancers present a higher trend than that for all COVID-19 patients, showing a significant difference (33.33% vs 16.09%, p
- Subjects :
- Oncology
medicine.medical_specialty
Disease
Applied Microbiology and Biotechnology
Transcriptome
03 medical and health sciences
prognostics
Internal medicine
Neoplasms
medicine
cancer
Humans
Clinical significance
HSPA5
Adverse effect
Lung cancer
Molecular Biology
Endoplasmic Reticulum Chaperone BiP
Ecology, Evolution, Behavior and Systematics
Heat-Shock Proteins
030304 developmental biology
0303 health sciences
transcriptomics
business.industry
SARS-CoV-2
Gene Expression Profiling
Case-control study
Cancer
COVID-19
Cell Biology
medicine.disease
Gene expression profiling
Case-Control Studies
business
Developmental Biology
Research Paper
Subjects
Details
- Language :
- English
- ISSN :
- 14492288
- Volume :
- 17
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- International Journal of Biological Sciences
- Accession number :
- edsair.doi.dedup.....4471a6b82a42e02fe7dc111852a8d12a