Tumor secretion of CCL22 activates intratumoral Treg infiltration and is independent prognostic predictor of breast cancer

Authors :: Fang Fang Liu
Ya Qing Li
Xiaojing Guo
Mei Jing Ren
Xinmin Zhang
Li Fu
Source :: PLoS ONE, Vol 8, Iss 10, p e76379 (2013), PLoS ONE
Publication Year :: 2013
Publisher :: Public Library of Science (PLoS), 2013.
Abstract: It has been reported that dense intratumoral infiltration of Foxp3 (+)Tregs (Tregs) was an independent factor for poor prognosis of breast cancer (BC) patients. However, the cytokines activating the Treg infiltration are not known. This study was undertaken to evaluate the role of CCL22 and TGF-β1 in this cascade and their prognostic significance for BC patients. 417 cases of invasive breast cancer were selected from the prior study cohort and the expressions of CCL22 and TGF-β1 were assessed by immunohistochemistry. It was identified that tumor secretion of CCL22 was positively correlated with the intratumoral Treg infiltration (P

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