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Antioxidant, photoprotective and inhibitory activity of tyrosinase in extracts of Dalbergia ecastaphyllum
- Source :
- PLoS ONE, Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP, PLoS ONE, Vol 13, Iss 11, p e0207510 (2018)
- Publication Year :
- 2018
- Publisher :
- Public Library of Science, 2018.
-
Abstract
- Dalbergia ecastaphyllum is a native Brazil plant with importance for beekeeping, and widely used in folk medicine. For the first time, the extracts of this plant were assessed for the presence of hydrophilic and lipophilic antioxidants, as well as inhibition of tyrosinase, free radicals scavenging and sunscreen protection. The antioxidant activity was evaluated by free radical scavenging (DPPH) and β-carotene bleaching assay. The tyrosinase inhibitory activity was evaluated and calculated the EC50. The photoprotective activity was measured using different concentrations of D. ecastaphyllum extracts. The Sun Protection Factor (SPF) of the samples was higher than 6, and the sample from Ilhéus showed the most pronounced photoprotective effect. Sample from Canavieiras presented the highest antioxidant activity by free radical scavenging DPPH and β-carotene bleaching method, with 92.41% and 48.34%, respectively. All samples inhibited the tyrosinase, especially the sample from Prado that was most effective (124.62 μg.mL-1). Significant negative correlation was found between flavonoid contents and inhibition of tyrosinase. The overall results provide relevant information about the Dalbergia ecastaphyllum species, indicating as potential material to cosmetic and pharmaceutical industry.<br />Funding: This work was supported by Grant number: 156870/2014-2 to D.V. de Morais and 305228/2013-7 to C.A.L. de Carvalho - Conselho Nacional de Desenvolvimento Científico e Tecnológico; Grant number: 88881.062167/2014-01 to M.L.M. Estevinho - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – CAPES; and Grant number: PET0008/2016 to L.A.G. Dias - Fundação de Amparo à Pesquisa do Estado da Bahia.
- Subjects :
- Chlorophyll
Pigments
Chemical Radicals
Antioxidant
Chloroplasts
DPPH
medicine.medical_treatment
Tyrosinase
Flavonoid
Plant Science
01 natural sciences
Biochemistry
Physical Chemistry
Antioxidants
chemistry.chemical_compound
Food science
Enzyme Inhibitors
Carotenoid
Materials
chemistry.chemical_classification
Multidisciplinary
Organic Compounds
Monophenol Monooxygenase
Chemical Reactions
Chemistry
Physical Sciences
Medicine
Bleaching
Cellular Structures and Organelles
Cellular Types
Research Article
Free Radicals
Radical
Science
Plant Cell Biology
Dalbergia
Materials Science
Ligation Independent Cloning
Research and Analysis Methods
Phenols
Plant Cells
medicine
Humans
Molecular Biology Techniques
Molecular Biology
EC50
Organic Pigments
Ethanol
010405 organic chemistry
Plant Extracts
010401 analytical chemistry
Organic Chemistry
Chemical Compounds
Biology and Life Sciences
Cell Biology
Carotenoids
0104 chemical sciences
Plant Leaves
chemistry
Alcohols
Sunscreening Agents
Cloning
Molecular Cloning
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 13
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....44851e93f26b04bfff94e8735736ee50