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High Cellular Monocyte Activation in People Living With Human Immunodeficiency Virus on Combination Antiretroviral Therapy and Lifestyle-Matched Controls Is Associated With Greater Inflammation in Cerebrospinal Fluid
- Source :
- Open Forum Infectious Diseases, OPEN FORUM INFECTIOUS DISEASES, Open forum infectious diseases, 4(3). Oxford University Press, Open Forum Infectious Diseases, 4(3). Oxford University Press
- Publication Year :
- 2017
-
Abstract
- Background Increased monocyte activation and intestinal damage have been shown to be predictive for the increased morbidity and mortality observed in treated people living with human immunodeficiency virus (PLHIV). Methods A cross-sectional analysis of cellular and soluble markers of monocyte activation, coagulation, intestinal damage, and inflammation in plasma and cerebrospinal fluid (CSF) of PLHIV with suppressed plasma viremia on combination antiretroviral therapy and age and demographically comparable HIV-negative individuals participating in the Comorbidity in Relation to AIDS (COBRA) cohort and, where appropriate, age-matched blood bank donors (BBD). Results People living with HIV, HIV-negative individuals, and BBD had comparable percentages of classical, intermediate, and nonclassical monocytes. Expression of CD163, CD32, CD64, HLA-DR, CD38, CD40, CD86, CD91, CD11c, and CX3CR1 on monocytes did not differ between PLHIV and HIV-negative individuals, but it differed significantly from BBD. Principal component analysis revealed that 57.5% of PLHIV and 62.5% of HIV-negative individuals had a high monocyte activation profile compared with 2.9% of BBD. Cellular monocyte activation in the COBRA cohort was strongly associated with soluble markers of monocyte activation and inflammation in the CSF. Conclusions People living with HIV and HIV-negative COBRA participants had high levels of cellular monocyte activation compared with age-matched BBD. High monocyte activation was predictive for inflammation in the CSF.
- Subjects :
- 0301 basic medicine
monocyte
COAGULATION
Viremia
Inflammation
CSF
CD38
Monocyte
immune activation
DISEASE
03 medical and health sciences
INNATE IMMUNE ACTIVATION
MARKERS
Medicine and Health Sciences
Major Article
medicine
Journal Article
CD64
CD40
Immune activation
biology
business.industry
HIV
Biology and Life Sciences
CHRONIC HIV-INFECTION
medicine.disease
3. Good health
CHEMOATTRACTANT PROTEIN-1
030104 developmental biology
Infectious Diseases
medicine.anatomical_structure
Oncology
inflammation
Immunology
Cohort
RISK-FACTORS
biology.protein
HEMOGLOBIN SCAVENGER RECEPTOR
GUT EPITHELIAL BARRIER
CD163
Neurology (clinical)
medicine.symptom
business
Subjects
Details
- Language :
- English
- ISSN :
- 23288957
- Volume :
- 4
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Open Forum Infectious Diseases
- Accession number :
- edsair.doi.dedup.....4489d6f60bd7ac650f26f062ab881410