[18F]-Fluorodeoxyglucose PET Imaging of Atherosclerosis

Authors :: Poul Flemming Høilund-Carlsen
Björn A. Blomberg
Source :: Blomberg, B A & Høilund-Carlsen, P F 2015, ' [ 18 F]-fluorodeoxyglucose PET imaging of atherosclerosis ', P E T Clinics, vol. 10, no. 1, pp. 1-7 . https://doi.org/10.1016/j.cpet.2014.09.001
Publication Year :: 2015
Publisher :: Elsevier BV, 2015.
Abstract: [(18)F]-fluorodeoxyglucose PET ((18)FDG PET) imaging has emerged as a promising tool for assessment of atherosclerosis. By targeting atherosclerotic plaque glycolysis, a marker for plaque inflammation and hypoxia, (18)FDG PET can assess plaque vulnerability and potentially predict risk of atherosclerosis-related disease, such as stroke and myocardial infarction. With excellent reproducibility, (18)FDG PET can be a surrogate end point in clinical drug trials, improving trial efficiency. This article summarizes key findings in the literature, discusses limitations of (18)FDG PET imaging of atherosclerosis, and reports recommendations to optimize imaging protocols.

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