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Repeated Transcranial Direct Current Stimulation Prevents Abnormal Behaviors Associated with Abstinence from Chronic Nicotine Consumption
- Source :
- Neuropsychopharmacology. 39:981-988
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- Successful available treatments to quit smoking remain scarce. Recently, the potential of transcranial direct current stimulation (tDCS) as a tool to reduce craving for nicotine has gained interest. However, there is no documented animal model to assess the neurobiological mechanisms of tDCS on addiction-related behaviors. To address this topic, we have developed a model of repeated tDCS in mice and used it to validate its effectiveness in relieving nicotine addiction. Anodal repeated tDCS was applied over the frontal cortex of Swiss female mice. The stimulation electrode (anode) was fixed directly onto the cranium, and the reference electrode was placed onto the ventral thorax. A 2 × 20 min/day stimulation paradigm for five consecutive days was used (0.2 mA). In the first study, we screened for behaviors altered by the stimulation. Second, we tested whether tDCS could alleviate abnormal behaviors associated with abstinence from nicotine consumption. In naive animals, repeated tDCS had antidepressant-like properties 3 weeks after the last stimulation, improved working memory, and decreased conditioned place preference for nicotine without affecting locomotor activity and anxiety-related behavior. Importantly, abnormal behaviors associated with chronic nicotine exposure (ie, depression-like behavior, increase in nicotine-induced place preference) were normalized by repeated tDCS. Our data show for the first time in an animal model that repeated tDCS is a promising, non-expensive clinical tool that could be used to reduce smoking craving and facilitate smoking cessation. Our animal model will be useful to investigate the mechanisms underlying the effects of tDCS on addiction and other psychiatric disorders.
- Subjects :
- Nicotine
medicine.medical_specialty
media_common.quotation_subject
medicine.medical_treatment
Drinking
Craving
Stimulation
Motor Activity
Eating
Mice
Physical medicine and rehabilitation
Memory
medicine
Animals
Nicotinic Agonists
Maze Learning
Psychiatry
Swimming
media_common
Pharmacology
Transcranial direct-current stimulation
Mental Disorders
Addiction
Body Weight
Age Factors
Recognition, Psychology
Transcranial Magnetic Stimulation
Conditioned place preference
Substance Withdrawal Syndrome
Transcranial magnetic stimulation
Disease Models, Animal
Psychiatry and Mental health
Conditioning, Operant
Smoking cessation
Female
Original Article
medicine.symptom
Psychology
medicine.drug
Subjects
Details
- ISSN :
- 1740634X and 0893133X
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Neuropsychopharmacology
- Accession number :
- edsair.doi.dedup.....449d629534a1c8dba7ad22cf8c432221