Synthesis of some new Methoxy Bridged Benzimidazolyl-Substituted phthalocyanines as potent inhibitors of urease

AKCAY, Hakki Turker/0000-0002-8502-9608 WOS: 000443574000012 In this study, the novel peripherally 4-[(2-methyl-1H-benzimidazol-1-yl)methoxy] substituted Zn(II) (3) Cu(II) (4), Co(II) (5) phthalocyanines were prepared and their structures were characterized spectro-scopically. The light absorption behaviors of the synthesized compounds (3-6) were studied by UV-Vis spectroscopy in the different concentration and different solvents were studied also. In addition, the urease inhibition activities of the synthesized compounds were also investigated. Among the synthesized molecules, compound 5 showed the best inhibitory effect against jack bean urease with IC50 values of 0.0034 +/- 0.0010 mu M. (C) 2018 Elsevier B.V. All rights reserved. Recep Tayyip Erdogan Universitesi - Research Funding [FBA-2017-788] This study was supported by Recep Tayyip Erdogan Universitesi - Research Funding - (Project no FBA-2017-788).