Back to Search
Start Over
Photoswitchable Micelles for the Control of Singlet-Oxygen Generation in Photodynamic Therapies
- Source :
- Biomacromolecules, 19(6), 2023-2033. AMER CHEMICAL SOC
- Publication Year :
- 2018
-
Abstract
- Inadvertent photosensitizer-activation and singlet-oxygen generation hampers clinical application of photodynamic therapies of superficial tumors or subcutaneous infections. Therefore, a reversible photoswitchable system was designed in micellar nanocarriers using ZnTPP as a photosensitizer and BDTE as a photoswitch. Singlet-oxygen generation upon irradiation didnot occur in closed-switch micelles with ZnTPP/BDTE feeding ratios >1:10. Deliberate switch closure/opening within 65-80 min was possible through thin layers of porcine tissue in vitro, increasing for thicker layers. Inadvertent opening of the switch by simulated daylight, took several tens of hours. Creating deliberate cell damage and prevention of inadvertent damage in vitro and in mice could be done at lower ZnTPP/BDTE feeding ratios (1:5) in open-switch micelles and at higher irradiation intensities than inferred from chemical clues to generate singlet-oxygen. The reduction of inadvertent photosensitizer activation in micellar nanocarriers, while maintaining the ability to kill tumor cells and infectious bacteria established here, brings photo dynamic therapies closer to clinical application.
- Subjects :
- Polymers and Plastics
02 engineering and technology
01 natural sciences
Micelle
Polyethylene Glycols
Lactones
Mice
chemistry.chemical_compound
Materials Chemistry
NANOPARTICLES
Photosensitizer
DRUG-DELIVERY
Micelles
Drug Carriers
Mice, Inbred BALB C
Photosensitizing Agents
Singlet Oxygen
Photoswitch
Singlet oxygen
PHOTOCHEMISTRY
3T3 Cells
021001 nanoscience & nanotechnology
Zinc
PORPHYRIN
Drug delivery
Female
0210 nano-technology
Porphyrins
SURFACE
Bioengineering
010402 general chemistry
Biomaterials
METAL-ORGANIC FRAMEWORKS
BLOCK-COPOLYMER MICELLES
medicine
Animals
Humans
Cell damage
Electron Spin Resonance Spectroscopy
PHOTOCHROMIC SWITCHES
medicine.disease
Porphyrin
Nanostructures
0104 chemical sciences
Photochemotherapy
chemistry
CELLS
PHOTOSENSITIZERS
Biophysics
Spectrophotometry, Ultraviolet
Nanocarriers
HeLa Cells
Subjects
Details
- Language :
- English
- ISSN :
- 15257797
- Database :
- OpenAIRE
- Journal :
- Biomacromolecules, 19(6), 2023-2033. AMER CHEMICAL SOC
- Accession number :
- edsair.doi.dedup.....44cf528c0618709739a2d5b7510e1c57