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Helically Chiral 1-Sulfur-Functionalized [6]Helicene: Synthesis, Optical Resolution, and Functionalization
- Source :
- Organic Letters. 19:3311-3314
- Publication Year :
- 2017
- Publisher :
- American Chemical Society (ACS), 2017.
-
Abstract
- The synthesis and optical resolution of helically chiral 5,6,9,10-tetrahydro-1-[6]helicenethiol and its subsequent transformations to enantiopure 1-sulfur-functionalized [6]helicenes are reported. A novel enantiopure [7]thiahelicene having a thiophene ring at the terminal position of the [6]helicene skeleton was synthesized.
- Subjects :
- 010405 organic chemistry
Chemistry
Stereochemistry
Organic Chemistry
Resolution (electron density)
chemistry.chemical_element
010402 general chemistry
Ring (chemistry)
01 natural sciences
Biochemistry
Combinatorial chemistry
Sulfur
0104 chemical sciences
chemistry.chemical_compound
Enantiopure drug
Helicene
Thiophene
Surface modification
Physical and Theoretical Chemistry
Subjects
Details
- ISSN :
- 15237052 and 15237060
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Organic Letters
- Accession number :
- edsair.doi.dedup.....44cfab65bc34d9c967d6930ba1b2aafb