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Temporal Genetic Modifications after Controlled Cortical Impact—Understanding Traumatic Brain Injury through a Systematic Network Approach
- Source :
- International Journal of Molecular Sciences, Vol 17, Iss 2, p 216 (2016), International Journal of Molecular Sciences; Volume 17; Issue 2; Pages: 216, International Journal of Molecular Sciences
- Publication Year :
- 2016
- Publisher :
- MDPI AG, 2016.
-
Abstract
- Traumatic brain injury (TBI) is a primary injury caused by external physical force and also a secondary injury caused by biological processes such as metabolic, cellular, and other molecular events that eventually lead to brain cell death, tissue and nerve damage, and atrophy. It is a common disease process (as opposed to an event) that causes disabilities and high death rates. In order to treat all the repercussions of this injury, treatment becomes increasingly complex and difficult throughout the evolution of a TBI. Using high-throughput microarray data, we developed a systems biology approach to explore potential molecular mechanisms at four time points post-TBI (4, 8, 24, and 72 h), using a controlled cortical impact (CCI) model. We identified 27, 50, 48, and 59 significant proteins as network biomarkers at these four time points, respectively. We present their network structures to illustrate the protein–protein interactions (PPIs). We also identified UBC (Ubiquitin C), SUMO1, CDKN1A (cyclindependent kinase inhibitor 1A), and MYC as the core network biomarkers at the four time points, respectively. Using the functional analytical tool MetaCore™, we explored regulatory mechanisms and biological processes and conducted a statistical analysis of the four networks. The analytical results support some recent findings regarding TBI and provide additional guidance and directions for future research.
- Subjects :
- 0301 basic medicine
Time Factors
Traumatic brain injury
Systems biology
Biology
Bioinformatics
Models, Biological
Article
Catalysis
drug target
Protein–protein interaction
Inorganic Chemistry
lcsh:Chemistry
03 medical and health sciences
0302 clinical medicine
Atrophy
Protein Interaction Mapping
medicine
Animals
Protein Interaction Maps
Physical and Theoretical Chemistry
Ubiquitin C
Molecular Biology
Stroke
lcsh:QH301-705.5
Spectroscopy
Microarray analysis techniques
Organic Chemistry
Computational Biology
Reproducibility of Results
brain injury
network biomarker
systems biology
protein–protein interaction
cell cycle
General Medicine
medicine.disease
Computer Science Applications
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
Brain Injuries
Algorithms
Biomarkers
030217 neurology & neurosurgery
Network approach
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 17
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....4502f0fd5dc3f76b153ed34f43b2feb0