Back to Search Start Over

CASE OF LEIOMYOMATOSIS PERITONEALIS DISSEMINATA TREATED WITH A GN-RH ANALOG

CASE OF LEIOMYOMATOSIS PERITONEALIS DISSEMINATA TREATED WITH A GN-RH ANALOG

Authors :
Nishimura H
Minoru Morimatsu
Michiaki Yakushiji
Iwanaga S
H Ishii
Y Kiyozuka
Akihiko Nakashima
S Imai
Source :
Oncology Reports.
Publication Year :
1995
Publisher :
Spandidos Publications, 1995.

Abstract

We report a rare case of leiomyomatosis peritonealis disseminata (LPD) which we attempted to treat by administering the Gn-RH superagonist, buserelin. A 48-year-old woman presented with a 6-month history of hypermenorrhea. Hysterectomy revealed a benign leiomyoma. Light and electron microscopic studies revealed that the tumors were composed of well- or poorly-differentiated smooth muscle cells. Their clinical appearance together with the mitotic figures found in tumor sections suggested an uncertain malignant potential. In the immunohistochemical study of intermediate filaments, antidesmin and anti-actin antibody reacted with tumor cells. Tumor re-growth in the pelvic cavity led to a second operation. The administration of the Gn-RH analogue, 900 mu g daily for two months, decreased the tumor size. The average final volume was 68.7% of the original. However, the tumors recurred during the next four weeks. The combined administration of the Gn-RH analogue and etoposide (25 mg x 2/day) did not prevent recurrence after a third operation. The serum level of immune-suppressive acid protein (IAP) was useful in monitoring the clinical course of this patient, finally diagnosed as having LPD.

Details

ISSN :
17912431 and 1021335X
Database :
OpenAIRE
Journal :
Oncology Reports
Accession number :
edsair.doi.dedup.....45156da6c0cb56c7d08b1a96fe9a9414
Full Text :
https://doi.org/10.3892/or.2.3.325