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Gene expression barcode values reveal a potential link between Parkinson’s disease and gastric cancer
- Source :
- Aging (Albany NY)
- Publication Year :
- 2021
- Publisher :
- Impact Journals, 2021.
-
Abstract
- Gastric cancer is a disease that develops from the lining of the stomach, whereas Parkinson's disease is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. Although these two diseases seem to be distinct from each other, increasing evidence suggests that they might be linked. To explore the linkage between these two diseases, differentially expressed genes between the diseased people and their normal controls were identified using the barcode algorithm. This algorithm transforms actual gene expression values into barcode values comprised of 1's (expressed genes) and 0's (silenced genes). Once the overlapped differentially expressed genes were identified, their biological relevance was investigated. Thus, using the gene expression profiles and bioinformatics methods, we demonstrate that Parkinson's disease and gastric cancer are indeed linked. This research may serve as a pilot study, and it will stimulate more research to investigate the relationship between gastric cancer and Parkinson's disease from the perspective of gene profiles and their functions.
- Subjects :
- Aging
Parkinson's disease
Degenerative Disorder
Central nervous system
barcode values
Disease
Biology
Stomach Neoplasms
Gene expression
medicine
Humans
Gene
Genetics
gene expression profiles
Stomach
gastric cancer
Gene Expression Profiling
differentially expressed genes (DEGs)
Cancer
Computational Biology
Parkinson Disease
Cell Biology
medicine.disease
medicine.anatomical_structure
Algorithms
Research Paper
Subjects
Details
- Language :
- English
- ISSN :
- 19454589
- Volume :
- 13
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Aging (Albany NY)
- Accession number :
- edsair.doi.dedup.....451efafd2ab3587633c9b02f62c7ae66