Back to Search
Start Over
Two genetic variants in telomerase-associated protein 1 are associated with stomach cancer risk
- Source :
- Journal of Human Genetics. 61:885-889
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- This study examined the impact of two single-nucleotide polymorphisms (SNPs) in the telomerase-associated protein 1 (TEP1) gene on the risk of breast, colorectal, hepatocellular, lung and stomach cancer. A significantly increased stomach cancer risk associated with the GG genotype at rs1760893 (odds ratio (OR)=1.64, 95% confidence interval (CI)=1.23-2.20, P=0.004) or CC genotype at rs1713423 (OR=2.40, 95% CI=1.88-3.07, P0.0001) was observed, compared with their wild-type counterpart. The GG genotype at rs1760893 was also associated with enhanced hepatocellular cancer susceptibility (OR=1.46, 95% CI=1.05-2.03, P=0.02). In classification and regression tree analysis, individuals carrying the CC genotype at rs1713423 had 2.69-fold increased risk of stomach cancer (95% CI=2.18-3.32, P0.0001) compared with the TT and TC genotypes. The current results suggested that genetic variants at TEP1 SNPs rs1760893 and rs1713423 may be associated significantly with increased risk of stomach cancer.
- Subjects :
- Adult
Male
Risk
0301 basic medicine
medicine.medical_specialty
Telomerase
Genotype
Biology
Polymorphism, Single Nucleotide
Linkage Disequilibrium
03 medical and health sciences
0302 clinical medicine
Stomach Neoplasms
Molecular genetics
Prevalence
Genetics
medicine
Humans
Genetic Predisposition to Disease
Epigenetics
Stomach cancer
Alleles
Genetic Association Studies
Genetics (clinical)
Aged
Models, Statistical
digestive, oral, and skin physiology
Genetic Variation
RNA-Binding Proteins
Middle Aged
medicine.disease
Human genetics
030104 developmental biology
Genetic epidemiology
Statistical genetics
030220 oncology & carcinogenesis
Medical genetics
Female
Carrier Proteins
Subjects
Details
- ISSN :
- 1435232X and 14345161
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Journal of Human Genetics
- Accession number :
- edsair.doi.dedup.....45211d169ffb903093f09df8ecde07b1