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Excessive Intake of High-Fructose Corn Syrup Drinks Induces Impaired Glucose Tolerance
- Source :
- Biomedicines, Vol 9, Iss 541, p 541 (2021), Biomedicines, Volume 9, Issue 5
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- The number of patients with diabetes was approximately 463 million worldwide in 2019, with almost 57.6% of this population concentrated in Asia. Asians often develop type 2 diabetes (T2D), even if they are underweight and consume a smaller amount of food. Soft drinks contain large amounts of sweeteners, such as high-fructose corn syrup (HFCS). Excessive intake of HFCS drinks is considered to be one of the causes of T2D. In the present study, we investigated the effect of excessive consumption of HFCS–water on glucose tolerance and obesity under conditions of controlled caloric intake using a mouse model. Three-week-old male ICR mice were divided into two groups and given free access to 10% HFCS–water or deionized water. The caloric intake was adjusted to be the same in both groups using a standard rodent diet. The excess HFCS–water intake did not lead to obesity, but led to impaired glucose tolerance (IGT) due to insulin-secretion defect. It affected glucose and fructose metabolism<br />for example, it decreased the expression of glucokinases, ketohexokinase, and glucose transporter 2 in the pancreas. These results suggest that excessive consumption of HFCS drinks, such as soft drinks, without a proper diet, induces nonobese IGT due to insulin-secretion defect.
- Subjects :
- 0301 basic medicine
insulin
food.ingredient
high-fructose corn syrup drinks
QH301-705.5
medicine.medical_treatment
Population
Medicine (miscellaneous)
030209 endocrinology & metabolism
Type 2 diabetes
Article
General Biochemistry, Genetics and Molecular Biology
Impaired glucose tolerance
03 medical and health sciences
0302 clinical medicine
food
Diabetes mellitus
medicine
Food science
Biology (General)
education
education.field_of_study
nonobesity
High-fructose corn syrup
business.industry
Insulin
medicine.disease
Obesity
Corn syrup
030104 developmental biology
impaired glucose tolerance
business
Subjects
Details
- Language :
- English
- ISSN :
- 22279059
- Volume :
- 9
- Issue :
- 541
- Database :
- OpenAIRE
- Journal :
- Biomedicines
- Accession number :
- edsair.doi.dedup.....452ef392f96a526d7988892a2bfcd789