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Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts
- Source :
- PLoS ONE, PLoS ONE, Vol 7, Iss 4, p e35876 (2012)
- Publication Year :
- 2018
- Publisher :
- Public Library of Science, 2018.
-
Abstract
- The type II transmembrane serine proteases TMPRSS2 and HAT activate influenza viruses and the SARS-coronavirus (TMPRSS2) in cell culture and may play an important role in viral spread and pathogenesis in the infected host. However, it is at present largely unclear to what extent these proteases are expressed in viral target cells in human tissues. Here, we show that both HAT and TMPRSS2 are coexpressed with 2,6-linked sialic acids, the major receptor determinant of human influenza viruses, throughout the human respiratory tract. Similarly, coexpression of ACE2, the SARS-coronavirus receptor, and TMPRSS2 was frequently found in the upper and lower aerodigestive tract, with the exception of the vocal folds, epiglottis and trachea. Finally, activation of influenza virus was conserved between human, avian and porcine TMPRSS2, suggesting that this protease might activate influenza virus in reservoir-, intermediate- and human hosts. In sum, our results show that TMPRSS2 and HAT are expressed by important influenza and SARS-coronavirus target cells and could thus support viral spread in the human host. peerReviewed
- Subjects :
- Disease reservoir
Viral Diseases
influenza virus
SARS-coronavirus
Swine
medicine.medical_treatment
viruses
Applied Microbiology
Respiratory System
Glycobiology
lcsh:Medicine
Gene Expression
Pathogenesis
urologic and male genital diseases
Severe Acute Respiratory Syndrome
Biochemistry
0302 clinical medicine
Emerging Viral Diseases
Zoonoses
lcsh:Science
Avian influenza A viruses
0303 health sciences
Multidisciplinary
biology
Immunochemistry
Serine Endopeptidases
Microbial Growth and Development
virus diseases
Orthomyxoviridae
3. Good health
Enzymes
Host-Pathogen Interaction
Severe acute respiratory syndrome-related coronavirus
Medical Microbiology
030220 oncology & carcinogenesis
Observational Studies
Receptors, Virus
Medicine
Infectious diseases
Angiotensin-Converting Enzyme 2
Coreceptors
Research Article
Proteases
Virus genetics
Histology
Viral Entry
Clinical Research Design
Peptidyl-Dipeptidase A
TMPRSS2
Microbiology
Viral Attachment
Virus
Cell Line
Birds
03 medical and health sciences
Virology
Microbial Control
Influenza, Human
medicine
Animals
Humans
Biology
Microbial Pathogens
030304 developmental biology
Disease Reservoirs
SARS
Protease
lcsh:R
Host Cells
Proteins
biology.organism_classification
Influenza
Enzyme Activation
Gastrointestinal Tract
Emerging Infectious Diseases
Cell culture
Sialic Acids
lcsh:Q
Viral Transmission and Infection
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- PLoS ONE, PLoS ONE, Vol 7, Iss 4, p e35876 (2012)
- Accession number :
- edsair.doi.dedup.....4532ad86eaa40851457b9cea4496a0da