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Author Correction: Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection

Authors :
Marianna Meschiari
Carlene Petes
Cristina Mussini
Sara De Biasi
Jordan Nieto
Francesco M. Galassi
Geneve Awong
Andrew A. Quong
Dongxia Lin
Luca Cicchetti
Fabio Facchinetti
Tommaso Trenti
Lucia Fidanza
Domenico Lo Tartaro
Mario Sarti
Rebecca Borella
Samuel Douglas
Anna Iannone
Chiara Leone
Marco Mattioli
Lara Gibellini
Annamaria Paolini
Giovanni Guaraldi
Isabella Neri
Andrea Cossarizza
Massimo Girardis
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021), Nature Communications
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

SARS-CoV-2 infection can affect all human beings, including pregnant women. Thus, understanding the immunological changes induced by the virus during pregnancy is nowadays of pivotal importance. Here, using peripheral blood from 14 pregnant women with asymptomatic or mild SARS-CoV-2 infection, we investigate cell proliferation and cytokine production, measure plasma levels of 62 cytokines, and perform a 38-parameter mass cytometry analysis. Our results show an increase in low density neutrophils but no lymphopenia or gross alterations of white blood cells, which display normal levels of differentiation, activation or exhaustion markers and show well preserved functionality. Meanwhile, the plasma levels of anti-inflammatory cytokines such as interleukin (IL)-1RA, IL-10 and IL-19 are increased, those of IL-17, PD-L1 and D-dimer are decreased, but IL-6 and other inflammatory molecules remain unchanged. Our profiling of antiviral immune responses may thus help develop therapeutic strategies to avoid virus-induced damages during pregnancy.

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
OpenAIRE
Journal :
Nature Communications
Accession number :
edsair.doi.dedup.....453b9eb8a720fc5460ce27fb682c3f23