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Author Correction: Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection
- Source :
- Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021), Nature Communications
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- SARS-CoV-2 infection can affect all human beings, including pregnant women. Thus, understanding the immunological changes induced by the virus during pregnancy is nowadays of pivotal importance. Here, using peripheral blood from 14 pregnant women with asymptomatic or mild SARS-CoV-2 infection, we investigate cell proliferation and cytokine production, measure plasma levels of 62 cytokines, and perform a 38-parameter mass cytometry analysis. Our results show an increase in low density neutrophils but no lymphopenia or gross alterations of white blood cells, which display normal levels of differentiation, activation or exhaustion markers and show well preserved functionality. Meanwhile, the plasma levels of anti-inflammatory cytokines such as interleukin (IL)-1RA, IL-10 and IL-19 are increased, those of IL-17, PD-L1 and D-dimer are decreased, but IL-6 and other inflammatory molecules remain unchanged. Our profiling of antiviral immune responses may thus help develop therapeutic strategies to avoid virus-induced damages during pregnancy.
- Subjects :
- Adult
2019-20 coronavirus outbreak
Coronavirus disease 2019 (COVID-19)
Adolescent
Neutrophils
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Science
General Physics and Astronomy
Translational immunology
Inflammation
Endogeny
Viral infection
Asymptomatic
General Biochemistry, Genetics and Molecular Biology
Young Adult
Pregnancy
Medicine
Humans
Pregnancy Complications, Infectious
Author Correction
Asymptomatic Infections
Multidisciplinary
business.industry
SARS-CoV-2
COVID-19
General Chemistry
Middle Aged
Virology
Cross-Sectional Studies
Case-Control Studies
Cytokines
Female
medicine.symptom
business
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 12
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....453b9eb8a720fc5460ce27fb682c3f23