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Linking the beneficial effects of current therapeutic approaches in diabetes to the vascular endothelin system
- Source :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publisher :
- The Authors. Published by Elsevier Inc.
-
Abstract
- The rising epidemic of diabetes worldwide is of significant concern. Although the ultimate objective is to prevent the development and find a cure for the disease, prevention and treatment of diabetic complications is very important. Vascular complications in diabetes, or diabetic vasculopathy, include macro- and microvascular dysfunction and represent the principal cause of morbidity and mortality in diabetic patients. Endothelial dysfunction plays a pivotal role in the development and progression of diabetic vasculopathy. Endothelin-1 (ET-1), an endothelial cell-derived peptide, is a potent vasoconstrictor with mitogenic, pro-oxidative and pro-inflammatory properties that are particularly relevant to the pathophysiology of diabetic vasculopathy. Overproduction of ET-1 is reported in patients and animal models of diabetes and the functional effects of ET-1 and its receptors are also greatly altered in diabetic conditions. The current therapeutic approaches in diabetes include glucose lowering, sensitization to insulin, reduction of fatty acids and vasculoprotective therapies. However, whether and how these therapeutic approaches affect the ET-1 system remain poorly understood. Accordingly, in the present review, we will focus on experimental and clinical evidence that indicates a role for ET-1 in diabetic vasculopathy and on the effects of current therapeutic approaches in diabetes on the vascular ET-1 system.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Type 2 diabetes
Disease
Bioinformatics
General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)
Internal medicine
Diabetes mellitus
Diabetes Mellitus
medicine
Animals
Humans
Endothelial dysfunction
General Pharmacology, Toxicology and Pharmaceutics
Receptor
Sensitization
Receptors, Endothelin
Biochemistry, Genetics and Molecular Biology(all)
business.industry
Endothelins
Insulin
Diabetes
General Medicine
medicine.disease
Vascular smooth muscle
Pathophysiology
ET-1
Endocrinology
medicine.anatomical_structure
ENDOTELINAS
Endothelium, Vascular
business
Diabetic Angiopathies
Subjects
Details
- Language :
- English
- ISSN :
- 00243205
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Life Sciences
- Accession number :
- edsair.doi.dedup.....45407b2a149ab65dbf09951f694b1133
- Full Text :
- https://doi.org/10.1016/j.lfs.2013.12.216