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Recombinant growth differentiation factor 11 influences short-term memory and enhances Sox2 expression in middle-aged mice
- Source :
- Behavioural Brain Research. 341:45-49
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Previous evidence suggests that a significant decline in cognitive ability begins during middle-age and continues to deteriorate with increase in age. Recent work has demonstrated the potential rejuvenation impact of growth differentiation factor-11 (GDF-11) in aged mice. We carried out experiments to evaluate the impact of a single dose of recombinant (rGDF-11) on short-term visual and spatial memory in middle-aged male mice. On the novel object recognition task, we observed middle-aged mice treated rGDF-11 showed improved performance on the novel object recognition task. However, middle-aged mice did not show increased expression of phosphorylated-Smad2/3, a downstream effector of GDF-11. We noted however that the expression of the transcription factor, Sox2 was increased within the dentate gyrus. Our data suggest that a single injection of rGDF-11 contributes to improvements in cognitive function of middle-aged animals, which may be critical in the preservation of short-term memory capacity in old age.
- Subjects :
- Male
0301 basic medicine
Aging
medicine.medical_specialty
Gene Expression
Short-term memory
Biology
law.invention
Random Allocation
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
SOX2
law
Internal medicine
medicine
Animals
Humans
Maze Learning
Transcription factor
Nootropic Agents
Spatial Memory
Effector
SOXB1 Transcription Factors
Dentate gyrus
Cognition
Recombinant Proteins
Growth Differentiation Factors
Mice, Inbred C57BL
Memory, Short-Term
030104 developmental biology
Endocrinology
Pattern Recognition, Visual
Bone Morphogenetic Proteins
Dentate Gyrus
GDF11
Recombinant DNA
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 01664328
- Volume :
- 341
- Database :
- OpenAIRE
- Journal :
- Behavioural Brain Research
- Accession number :
- edsair.doi.dedup.....454288ab679e9489ed236437a9ccc7dd