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Algorithm of optimization of fractionated radiotherapy within its combination with antiangiogenic therapy by means of mathematical modeling
- Source :
- ITM Web of Conferences, Vol 31, p 02001 (2020)
- Publication Year :
- 2020
- Publisher :
- EDP Sciences, 2020.
-
Abstract
- Antiangiogenic therapy is the anti-tumor treatment, that leads to the cessation of blood vessels formation and subsequent nutrient deprivation of the tumor. One of its frequently occurring effects is the transient improvement of tumor oxygenation, which lasts several days and leads to increased efficiency of successive exposure to radiation. It is followed by an escalation of hypoxia, and therefore the addition of antiangiogenic therapy to the whole course of fractionated radiotherapy has an ambiguous effect. Previously we have developed a mathematical model of such combined anti-tumor treatment. Herein we present an algorithm of optimization of radiotherapy fractionation, which aim is to find the most optimal distribution of irradiation doses in order to increase the efficiency of such combined treatment. We demonstrate an example of its work and discuss its further application.
- Subjects :
- lcsh:T58.5-58.64
Fractionated radiotherapy
lcsh:Information technology
0206 medical engineering
Antiangiogenic therapy
Radiotherapy fractionation
02 engineering and technology
Tumor Oxygenation
Hypoxia (medical)
020601 biomedical engineering
01 natural sciences
010101 applied mathematics
Combined treatment
medicine
0101 mathematics
medicine.symptom
Algorithm
Subjects
Details
- ISSN :
- 22712097
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- ITM Web of Conferences
- Accession number :
- edsair.doi.dedup.....457f09c7441ca410c10cbf41483523d6
- Full Text :
- https://doi.org/10.1051/itmconf/20203102001