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Mediation effects of thyroid function in the associations between phthalate exposure and glucose metabolism in adults
- Source :
- Environmental Pollution. 278:116799
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- The mediating influence of thyroid function on the association of phthalate exposure with glucose metabolism, including insulin resistance, remains unclear. We explored the mediating influence of thyroid hormone levels on the phthalate exposure–insulin resistance association. This cross-sectional study of 217 Taiwanese adults assessed insulin resistance (Homeostatic Model Assessment for Insulin Resistance, HOMA-IR scores) and the levels of 11 urinary phthalate metabolites and 5 thyroid hormones. Multiple regression models were used to analyze the associations among serum thyroid hormone levels, urinary phthalate metabolite levels, and HOMA-IR scores. The mediation analysis assessed the influence of thyroid function on the phthalate exposure–HOMA-IR association. Our data indicated urinary mono-ethylhexyl phthalate (MEHP) levels was negatively associated with free thyroxine (T4) (β = −0.018; 95% confidence interval [CI]: −0.031, −0.005) and positively associated with HOMA-IR scores (β = 0.051, 95% CI: 0.012, 0.090). The study also revealed urinary mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) levels was negatively associated with free T4 (β = −0.036, 95% CI: −0.056, −0.017) and HOMA-IR (β = 0.070, 95% CI: 0.013, 0.126). Free T4 and HOMA-IR had a negative association (β = −0.757, 95% CI: −1.122, −0.392). In the mediation analysis, free T4 mediated 24% and 35% of the associations of urinary MEHP and MEOHP with HOMA-IR, respectively. Our findings revealed the mediating role of thyroid function in the phthalate exposure–glucose metabolism association in adults.
- Subjects :
- medicine.medical_specialty
010504 meteorology & atmospheric sciences
Health, Toxicology and Mutagenesis
Urinary system
Phthalic Acids
Thyroid Gland
010501 environmental sciences
Carbohydrate metabolism
Toxicology
01 natural sciences
chemistry.chemical_compound
Insulin resistance
Diethylhexyl Phthalate
Internal medicine
medicine
0105 earth and related environmental sciences
business.industry
Thyroid
Phthalate
Environmental Exposure
General Medicine
medicine.disease
Pollution
Cross-Sectional Studies
Glucose
Endocrinology
medicine.anatomical_structure
chemistry
Homeostatic model assessment
Thyroid function
business
Hormone
Subjects
Details
- ISSN :
- 02697491
- Volume :
- 278
- Database :
- OpenAIRE
- Journal :
- Environmental Pollution
- Accession number :
- edsair.doi.dedup.....458bd7432e9e73ab0f4fe8609e6042ef