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Umbilical Cord Concentrations of Selected Heavy Metals and Risk for Orofacial Clefts
- Source :
- Environmental Science & Technology. 52:10787-10795
- Publication Year :
- 2018
- Publisher :
- American Chemical Society (ACS), 2018.
-
Abstract
- Although arsenic (As), cadmium (Cd), lead (Pb), and nickel (Ni) have the ability to induce orofacial clefts (OFCs) in rodents, evidence is absent from human epidemiological investigations with markers of in utero exposure. We investigated the associations between concentrations of As, Cd, Pb, and Ni in umbilical cord tissues and risk of OFCs, and the interactions between each pair of metals on OFC risk in a case-control study. Umbilical cord concentrations of metals were determined by inductively coupled plasma mass spectrometry in 92 OFC cases and 200 nonmalformed controls. Concentrations above the median of all subjects was associated with an elevated OFC risk of 8.36-fold for As, 7.22-fold for Cd, 15.32-fold for Pb, and 6.79-fold for Ni. Concentrations of As, Cd, Pb, and Ni were also associated with risks for OFC subtypes. When metal concentrations were divided into tertiles by levels of metal concentrations of all subjects, dose-response relationships of risks for total OFCs and subtypes with As, Cd, Pb, and Ni concentrations were demonstrated. Significant synergistic interaction between As and Ni on the risk of OFCs was also observed. Therefore, elevated in utero exposure to As, Cd, Pb, and Ni may increase the risks of OFCs in newborns.
- Subjects :
- medicine.medical_specialty
Cleft Lip
chemistry.chemical_element
010501 environmental sciences
01 natural sciences
Umbilical cord
Umbilical Cord
03 medical and health sciences
0302 clinical medicine
Metals, Heavy
Internal medicine
mental disorders
medicine
Humans
Environmental Chemistry
030212 general & internal medicine
Inductively coupled plasma mass spectrometry
Arsenic
0105 earth and related environmental sciences
Cadmium
Infant, Newborn
Heavy metals
General Chemistry
Cleft Palate
medicine.anatomical_structure
Endocrinology
nervous system
chemistry
In utero
Case-Control Studies
psychological phenomena and processes
Subjects
Details
- ISSN :
- 15205851 and 0013936X
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Environmental Science & Technology
- Accession number :
- edsair.doi.dedup.....45a6fb2860b89503a8770e2d18f620f4