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Dopaminergic and noradrenergic modulation of stress-induced alterations in brain activation associated with goal-directed behaviour
- Source :
- Journal of Psychopharmacology, 35(12), 1449-1463. Sage Publications Ltd, Journal of Psychopharmacology (Oxford, England), Journal of Psychopharmacology, 35(12):02698811211044679, 1449-1463. SAGE Publications Ltd
- Publication Year :
- 2021
-
Abstract
- Background: Acute stress is thought to reduce goal-directed behaviour, an effect purportedly associated with stress-induced release of catecholamines. In contrast, experimentally increased systemic catecholamine levels have been shown to increase goal-directed behaviour. Whether experimentally increased catecholamine function can modulate stress-induced reductions in goal-directed behaviour and its neural substrates, is currently unknown. Aim: To assess whether and how experimentally induced increases in dopamine and noradrenaline contribute to the acute stress effects on goal-directed behaviour and associated brain activation. Methods: One hundred participants underwent a stress induction protocol (Maastricht acute stress test; MAST) or a control procedure and received methylphenidate (MPH) (40 mg, oral) or placebo according to a 2 × 2 between-subjects design. In a well-established instrumental learning paradigm, participants learnt stimulus–response–outcome associations, after which rewards were selectively devalued. Participants’ brain activation and associated goal-directed behaviour were assessed in a magnetic resonance imaging scanner at peak cortisol/MPH concentrations. Results: The MAST and MPH increased physiological measures of stress (salivary cortisol and blood pressure), but only MAST increased subjective measures of stress. MPH modulated stress effects on activation of brain areas associated with goal-directed behaviour, including insula, putamen, amygdala, medial prefrontal cortex, frontal pole and orbitofrontal cortex. However, MPH did not modulate the tendency of stress to induce a reduction in goal-directed behaviour. Conclusion: Our neuroimaging data suggest that MPH-induced increases in dopamine and noradrenaline reverse stress-induced changes in key brain regions associated with goal-directed behaviour, while behavioural effects were absent. These effects may be relevant for preventing stress-induced maladaptive behaviour like in addiction or binge eating disorder.
- Subjects :
- Male
Hydrocortisone
Dopamine
goal-directed behaviour
Norepinephrine
stress
INSTRUMENTAL BEHAVIOR
Pharmacology (medical)
Cerebral Cortex
Neurotransmitter Agents
neuroimaging
Chemistry
MEDIAL PREFRONTAL CORTEX
Dopaminergic
Putamen
Amygdala
Original Papers
Magnetic Resonance Imaging
Ventral tegmental area
Psychiatry and Mental health
medicine.anatomical_structure
LOCUS-COERULEUS
Female
Goals
medicine.drug
Brain activation
Adult
Adolescent
INDUCED INCREASE
PSYCHOSOCIAL STRESS
Memory systems
DRUG-ADDICTION
Young Adult
POSITRON-EMISSION-TOMOGRAPHY
Reward
medicine
Humans
Acute stress
Pharmacology
Stress induced
Association Learning
VENTRAL TEGMENTAL AREA
Methylphenidate
Locus coeruleus
Conditioning, Operant
MEMORY-SYSTEMS
Neuroscience
Stress, Psychological
INDUCED RELAPSE
Subjects
Details
- Language :
- English
- ISSN :
- 02698811
- Database :
- OpenAIRE
- Journal :
- Journal of Psychopharmacology, 35(12), 1449-1463. Sage Publications Ltd, Journal of Psychopharmacology (Oxford, England), Journal of Psychopharmacology, 35(12):02698811211044679, 1449-1463. SAGE Publications Ltd
- Accession number :
- edsair.doi.dedup.....45a79756d0a64820c767828e2714ddef