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Interleukin-1 beta (IL-1 beta) expression in human blood mononuclear phagocytes is differentially regulated by granulocyte-macrophage colony- stimulating factor (GM-CSF), M-CSF, and IL-3
- Source :
- Blood. 79:1260-1265
- Publication Year :
- 1992
- Publisher :
- American Society of Hematology, 1992.
-
Abstract
- In this report we show that recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) and rh macrophage (M)-CSF induce accumulation of interleukin-1 beta (IL-1 beta) mRNA in blood-derived mononuclear phagocytes (MNP). GM-CSF and M-CSF treatment of MNP is also associated with IL-1 beta secretion. Regulation of GM- and M-CSF- induced IL-1 beta mRNA expression involves transcriptional and posttranscriptional mechanisms. However, the action of IL-3 on synthesis of IL-1 beta mRNA differs from that of other CSFs: While GM- CSF and M-CSF induce binding activity of the nuclear factor (NF) kappa B, IL-3 treatment of MNP has no profound effect on NF kappa B binding to DNA. Moreover, IL-3 decreases the transcription rate of the IL-1 beta gene and has only little effect on stability of IL-1 beta mRNA, which is increased by GM- and M-CSF. However, IL-3 enhances M-CSF- induced accumulation of IL-1 beta mRNA by unknown posttranscriptional means that may relate to an increased expression of M-CSF receptor (ie, c-fms) mRNA, detectable in mononuclear phagocytes on exposure to IL-3.
- Subjects :
- Macrophage colony-stimulating factor
medicine.medical_specialty
Phagocyte
Immunology
Cell Biology
Hematology
Biology
Biochemistry
Molecular biology
Peripheral blood mononuclear cell
Granulocyte macrophage colony-stimulating factor
Endocrinology
medicine.anatomical_structure
Internal medicine
Gene expression
medicine
Macrophage
Beta (finance)
medicine.drug
Interleukin 3
Subjects
Details
- ISSN :
- 15280020 and 00064971
- Volume :
- 79
- Database :
- OpenAIRE
- Journal :
- Blood
- Accession number :
- edsair.doi.dedup.....45c56dd76d2a3f890371c6f0dda84fe7
- Full Text :
- https://doi.org/10.1182/blood.v79.5.1260.bloodjournal7951260