Back to Search Start Over

Use of WATCH antibiotics prior to presentation to the hospital in rural Burkina Faso

Authors :
Daniel VALIA
Brecht Ingelbeen
Bérenger Kaboré
Ibrahima Karama
Marjan Peeters
Palpouguini Lompo
Erika Vlieghe
Annelies Post
Janneke Cox
Quirijn de Mast
Annie Robert
Marianne A.B. van der Sande
Hector Rodriguez Villalobos
Andre van der Ven
Halidou Tinto
Jan Jacobs
Rodriguez-Villalobos, Hector/0000-0003-3041-1591
VALIA
Daniel/0000-0003-0851-9352
Ingelbeen, Brecht/0000-0002-2214-6858
Valia, Daniel
Ingelbeen, Brecht
Kabore, Berenger
Karama, Ibrahima
Peeters, Marjan
Lompo, Palpouguini
Vlieghe, Erika
Post, Annelies
COX, Janneke
de Mast, Quirijn
Robert, Annie
van der Sande, Marianne A. B.
Villalobos, Hector Rodriguez
van der Ven, Andre
Tinto, Halidou
Jacobs, Jan
UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale
UCL - (SLuc) Service de microbiologie
UCL - SSS/IREC/EPID - Pôle d'épidémiologie et biostatistique
Source :
Antimicrobial resistance & infection control, Antimicrobial Resistance and Infection Control, 11, 1, Antimicrobial resistance and infection control, Vol. 11, no. 1, p. 59 [1-7] (2022), Antimicrobial Resistance and Infection Control, 11
Publication Year :
2022
Publisher :
BMC, 2022.

Abstract

BackgroundIn low- and middle-income countries, the prevalence of antimicrobial resistance (AMR) is increasing. To control AMR, WHO recommends monitoring antibiotic use, in particular Watch antibiotics. These are critically important antibiotics, with restricted use because at risk of becoming ineffective due to increasing AMR. We investigated pre-hospital antibiotic use in rural Burkina Faso.MethodsDuring 2016–2017, we collected data from patients aged > 3 months presenting with severe acute fever to the rural hospital of Nanoro Health District, Burkina Faso, including antibiotic use in the two weeks prior to consultation or hospitalization. We analysed reported antibiotic use by applying the WHO Access, Watch, Reserve classification.ResultsOf 920 febrile participants (63.0% ≤ 14 years), pre-hospital antibiotic use was reported by 363 (39.5%). Among these 363, microbiological diagnoses were available for 275 (75.8%) patients, of whom 162 (58.9%) were non-bacterial infections. Use of more than one antibiotic was reported by 58/363 (16.0%) participants. Of 491 self-referred patients who did not previously visit a primary health care center, 131 (26.7%) reported antibiotic use. Of 424 antibiotics reported, 265 (62.5%) were Access and 159 (37.5%) Watch antibiotics. Watch antibiotic use was more frequent among patients > 14 year olds (51.1%) compared to those 0–14 year old (30.7%,p p = 0.004). Most frequently reported Watch antibiotics were ceftriaxone (114, 71.7%) and ciprofloxacin (32, 20.1%).ConclusionThe reported frequent use of Watch group antibiotics among febrile patients prior to presentation to the hospital in rural Burkina Faso highlights the need to develop targeted interventions to improve antibiotic use in community settings as part of strengthening antibiotic stewardship in low- and middle-income countries. This should include facilitating referral, access to qualified prescribers and diagnostic tools in rural primary health care centers.Trial registrationClinicalTrials.gov identifier: NCT02669823. Registration date was February 1, 2016.

Details

ISSN :
20472994
Database :
OpenAIRE
Journal :
Antimicrobial resistance & infection control, Antimicrobial Resistance and Infection Control, 11, 1, Antimicrobial resistance and infection control, Vol. 11, no. 1, p. 59 [1-7] (2022), Antimicrobial Resistance and Infection Control, 11
Accession number :
edsair.doi.dedup.....45ca741f48252b9936f363e9b3a7e6c8