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Trained innate lymphoid cells in allergic diseases
- Source :
- Allergology International, Vol 70, Iss 2, Pp 174-180 (2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier B.V., 2021.
-
Abstract
- Group 2 innate lymphoid cells (ILC2s) reside in peripheral tissues such as the lungs, skin, nasal cavity, and gut and provoke innate type 2 immunity against allergen exposure, parasitic worm infection, and respiratory virus infection by producing TH2 cytokines. Recent advances in understanding ILC2 biology revealed that ILC2s can be trained by IL-33 or allergic inflammation, are long-lived, and mount memory-like type 2 immune responses to any other allergens afterwards. In contrast, IL-33, together with retinoic acid, induces IL-10-producing immunosuppressive ILC2s. In this review, we discuss how the allergic cytokine milieu and other immune cells direct the generation of trained ILC2s with immunostimulatory or immunosuppressive recall capability in allergic diseases and infections associated with type 2 immunity. The molecular mechanisms of trained immunity by ILCs and the physiological relevance of trained ILC2s are also discussed.
- Subjects :
- lcsh:Immunologic diseases. Allergy
0301 basic medicine
IL-10-producing ILC2
Retinoic acid
Exhausted-like ILC2
Cell Communication
Th2 cytokines
Trained immunity
Trained ILC2
Allergic inflammation
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Immune system
Immunity
Hypersensitivity
Alarmins
Animals
Humans
Immunology and Allergy
Medicine
Lymphocytes
Neurons
business.industry
Cytokine milieu
Innate lymphoid cell
General Medicine
Interleukin-33
Lipids
Immunity, Innate
Memory-like ILC2
Interleukin-10
030104 developmental biology
030228 respiratory system
chemistry
Virus Diseases
Immunology
Inflammation Mediators
ALLERGEN EXPOSURE
lcsh:RC581-607
business
Subjects
Details
- Language :
- English
- ISSN :
- 13238930
- Volume :
- 70
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Allergology International
- Accession number :
- edsair.doi.dedup.....45d0c12211f0341388d7d266d9195f56