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Potential of rifamides to inhibit TNF-induced NF-kappaB activation

Authors :
Brian M. J. Foxwell
Ali A. Pahlevan
Laura Bradley
Clive Smith
David J. M. Wright
Source :
Journal of Antimicrobial Chemotherapy. 49:531-534
Publication Year :
2002
Publisher :
Oxford University Press (OUP), 2002.

Abstract

Rifamides are important components in the treatment of tuberculosis. However, it is well documented that these drugs can have immunosuppressive activity, a property of these drugs that is particularly relevant to AIDS patients. In this study, we have shown that a number of rifamide analogues have the potential to block tumour necrosis factor (TNF)- or phorbol myristate acetate-induced NF-kappaB activation. As TNF is important in the host defence against tuberculosis, suppression of this activity may provide a potential mechanism of rifamide immunosuppressive activity.

Details

ISSN :
14602091
Volume :
49
Database :
OpenAIRE
Journal :
Journal of Antimicrobial Chemotherapy
Accession number :
edsair.doi.dedup.....45d58fd1bb53974945ff605a06092525
Full Text :
https://doi.org/10.1093/jac/49.3.531