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MAGE genes: Prognostic indicators in AL amyloidosis patients
- Source :
- Journal of Cellular and Molecular Medicine
- Publication Year :
- 2019
- Publisher :
- John Wiley and Sons Inc., 2019.
-
Abstract
- A high frequency of MAGE‐CT (cancer testis) antigens are expressed in Multiple Myeloma (MM) patients; however, in other plasma cell dyscrasias, their potential function remains unclear. We measured the expression of MAGE‐CT genes (MAGE‐C1/CT7, MAGE‐A3, MAGE‐C2/CT10) in 105 newly diagnosed amyloid light‐chain (AL) amyloidosis patients between June 2013 and January 2018 at Peking University People's Hospital using real‐time quantitative polymerase chain reaction. In the newly diagnosed AL patients, the positive expression rates of patients with MAGE‐C1/CT7, MAGE‐C2/CT10 and MAGE‐A3 were 83.8% (88/105), 56.71% (38/67) and 22.0% (13/59) respectively. There was no significant correlation between organ propensity and MAGE‐CT gene expression. Changes in the MAGE‐C1/CT7 levels were consistent with a therapeutic effect. The expression levels of MAGE‐C1/CT7, MAGE‐C2/CT10 and MAGE‐A3 provide potentially effective clinical indicators for auxiliary diagnoses and monitoring treatment efficacy in AL amyloidosis patients.
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
endocrine system
Amyloid
cancer‐testis antigen gene
Plasma cell
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Antigens, Neoplasm
Internal medicine
Gene expression
medicine
AL amyloidosis
Humans
Immunoglobulin Light-chain Amyloidosis
real‐time quantitative polymerase chain reaction
neoplasms
Multiple myeloma
Aged
Aged, 80 and over
business.industry
Amyloidosis
Therapeutic effect
amyloid light‐chain amyloidosis
Cell Biology
Original Articles
Middle Aged
medicine.disease
Prognosis
Survival Analysis
030104 developmental biology
medicine.anatomical_structure
Real-time polymerase chain reaction
030220 oncology & carcinogenesis
Molecular Medicine
Original Article
Female
business
Subjects
Details
- Language :
- English
- ISSN :
- 15824934 and 15821838
- Volume :
- 23
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Journal of Cellular and Molecular Medicine
- Accession number :
- edsair.doi.dedup.....45ee28a06187aeffb4633930c938e8ab