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Pea-like nanocabins enable autonomous cruise and step-by-step drug pushing for deep tumor inhibition
- Source :
- Nanomedicine: Nanotechnology, Biology and Medicine. 18:122-134
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Pea-like nanocabins (HA@APT§DOX) were designed for deep tumor inhibition. The AS1411 aptamer (APT) constituted "core shelf" which guaranteed DOX "beans" could be embedded, while the outer HA acted as "pea shell" coating. During the circulation (primary orbit), HA@APT§DOX could autonomously cruise until leak through tumor vasculature. Upon tumor superficial site, the "pea shell" could be degraded by highly expressed hyaluronic acid enzymes (HAase) and peel-off, resulting in orbit changing of released APT§DOX to reach the deep tumor tissue. Furthermore, APT§DOX could be specifically uptaken into A549 tumor cells (secondary orbit). Finally, DOX was released under the acidic environment of lysosome, and delivered into nuclear (targeting orbit) to achieve drug pushing for deep tumor inhibition. More importantly, the in vivo imaging and anti-tumor effects evaluations showed that these nanocabins could effectively enhance drugs accumulation in tumor sites and inhibit tumor growth, with reduced systemic toxicity in 4T1 tumor-bearing mice.
- Subjects :
- Drug
media_common.quotation_subject
Tumor inhibition
Biomedical Engineering
Pharmaceutical Science
Medicine (miscellaneous)
Antineoplastic Agents
Apoptosis
Bioengineering
02 engineering and technology
Tumor vasculature
Mice
03 medical and health sciences
chemistry.chemical_compound
Neoplasms
Spheroids, Cellular
Lysosome
Hyaluronic acid
medicine
Animals
Humans
Tissue Distribution
General Materials Science
Tumor growth
Hyaluronic Acid
030304 developmental biology
media_common
0303 health sciences
Chemistry
Peas
Aptamers, Nucleotide
021001 nanoscience & nanotechnology
Endocytosis
Cell biology
Drug Liberation
medicine.anatomical_structure
Systemic toxicity
As1411 aptamer
A549 Cells
Doxorubicin
Nanoparticles
Molecular Medicine
0210 nano-technology
Subjects
Details
- ISSN :
- 15499634
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Nanomedicine: Nanotechnology, Biology and Medicine
- Accession number :
- edsair.doi.dedup.....45f929a681712d7e18a0b06fcd27b477