Back to Search
Start Over
New method of evaluating sperm morphology with predictive value for human in vitro fertilization
- Source :
- Urology. 30:248-251
- Publication Year :
- 1987
- Publisher :
- Elsevier BV, 1987.
-
Abstract
- A prospective study was planned to evaluate sperm morphology as a parameter to predict the fertilization outcome in an in vitro fertilization program. Couples applying to in vitro fertilization were admitted into this project when the sperm concentration was greater than 20 million per mL and motility greater than 30 per cent. Based on new strict criteria for evaluating normal sperm morphology, patients were divided prospectively into 2 groups. In group I (25 patients) normal sperm morphology was less than 14 per cent, and in group II (71 patients) normal sperm morphology was greater than 14 per cent, using a threshold established previously. Multiple regression analysis was used to evaluate different parameters: concentration, motility, and morphology against the dependent variables, fertilization, and cleavage. The only factor which was significantly correlated with fertilization and cleavage was normal sperm morphology (P less than 0.0001). The fertilization rate (per oocyte) and the cleavage rate were 49.4 per cent and 47.6 per cent in group I and 88.3 per cent and 87 per cent in group II (P less than 0.0001). The ongoing pregnancy rate per laparoscopy and per embryo transfer was 4 per cent and 5.5 per cent, respectively, in group I and 18.3 per cent and 18.5 per cent, respectively, in group II (no significant difference). This study demonstrates the value of analyzing sperm morphology using the criteria recommended in terms of predicting fertilization and perhaps pregnancy outcome. Patients can be better counseled and the probability of fertilization or no fertilization can be more accurately established. Furthermore a trend is shown in the pregnancy rate that may indicate the importance of the male genome in establishing a pregnancy.
- Subjects :
- Male
Urology
medicine.medical_treatment
Fertilization in Vitro
Andrology
Human fertilization
Predictive Value of Tests
Pregnancy
medicine
Humans
Prospective Studies
Sperm motility
In vitro fertilisation
Sperm Count
business.industry
Embryo Transfer
medicine.disease
Oocyte
Spermatozoa
Sperm
Embryo transfer
Pregnancy rate
medicine.anatomical_structure
Sperm Motility
Regression Analysis
Female
business
Subjects
Details
- ISSN :
- 00904295
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Urology
- Accession number :
- edsair.doi.dedup.....45fd330fc9a3e742ccd5c2f97c50a006