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Delta-like ligand 4 in hepatocellular carcinoma intrinsically promotes tumour growth and suppresses hepatitis B virus replication
- Source :
- World journal of gastroenterology. 24(34)
- Publication Year :
- 2018
-
Abstract
- To investigate the role of Delta-like ligand 4 (DLL4) on tumour growth in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC)We suppressedEighteen days after implantation, tumour volume in mice implanted with shDLL4 HepG2.2.15 was significantly smaller than in mice implanted with control HepG2.2.15 (This study demonstrates that DLL4 is important in regulating the tumour growth of HBV-associated HCC as well as the neovascularization and suppression of HBV replication.
- Subjects :
- 0301 basic medicine
Male
Vascular Endothelial Growth Factor A
Hepatitis B virus
Carcinoma, Hepatocellular
Notch signaling pathway
Mice, Nude
medicine.disease_cause
Virus Replication
03 medical and health sciences
Mice
Viral Proteins
0302 clinical medicine
Cell Line, Tumor
medicine
Animals
Humans
RNA, Small Interfering
education
Adaptor Proteins, Signal Transducing
education.field_of_study
Mice, Inbred BALB C
Delta-like ligand 4
Neovascularization, Pathologic
Chemistry
Calcium-Binding Proteins
Liver Neoplasms
Gastroenterology
General Medicine
Hep G2 Cells
Ligand (biochemistry)
medicine.disease
Vascular Endothelial Growth Factor Receptor-2
Xenograft Model Antitumor Assays
digestive system diseases
Replication (computing)
030104 developmental biology
030220 oncology & carcinogenesis
Hepatocellular carcinoma
Gene Knockdown Techniques
Cancer research
Intercellular Signaling Peptides and Proteins
Subjects
Details
- ISSN :
- 22192840
- Volume :
- 24
- Issue :
- 34
- Database :
- OpenAIRE
- Journal :
- World journal of gastroenterology
- Accession number :
- edsair.doi.dedup.....45feca45ea62b1616cc72cc965121694