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DES-ncRNA: A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-mining
- Source :
- RNA Biology
- Publication Year :
- 2017
-
Abstract
- Noncoding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long ncRNAs (lncRNAs), are important players in diseases and emerge as novel drug targets. Thus, unraveling the relationships between ncRNAs and other biomedical entities in cells are critical for better understanding ncRNA roles that may eventually help develop their use in medicine. To support ncRNA research and facilitate retrieval of relevant information regarding miRNAs and lncRNAs from the plethora of published ncRNA-related research, we developed DES-ncRNA (www.cbrc.kaust.edu.sa/des_ncrna). DES-ncRNA is a knowledgebase containing text- and data-mined information from public scientific literature and other public resources. Exploration of mined information is enabled through terms and pairs of terms from 19 topic-specific dictionaries including, for example, antibiotics, toxins, drugs, enzymes, mutations, pathways, human genes and proteins, drug indications and side effects, mutations, diseases, etc. DES-ncRNA contains approximately 878,000 associations of terms from these dictionaries of which 36,222 (5,373) are with regards to miRNAs (lncRNAs). We provide several ways to explore information regarding ncRNAs to users including controlled generation of association networks as well as hypotheses generation. We show an example how DES-ncRNA can aid research on Alzheimer disease and suggest potential therapeutic role for Fasudil. DES-ncRNA is a powerful tool that can be used on its own or as a complement to the existing resources, to support research in human ncRNA. To our knowledge, this is the only knowledgebase dedicated to human miRNAs and lncRNAs derived primarily through literature-mining enabling exploration of a broad spectrum of associated biomedical entities, not paralleled by any other resource.
- Subjects :
- 0301 basic medicine
data-mining
Knowledge Bases
Dictionaries as Topic
Scientific literature
Computational biology
Biology
Bioinformatics
Noncoding RNA
03 medical and health sciences
Broad spectrum
0302 clinical medicine
Alzheimer Disease
literature-mining
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
Data Mining
Humans
long noncoding RNA
Molecular Biology
microRNA
text-mining
Cell Biology
bioinformatics
Non-coding RNA
information integration
Long non-coding RNA
3. Good health
knowledgebase
MicroRNAs
Gene Ontology
030104 developmental biology
Disease Progression
RNA, Long Noncoding
Human genome
Alzheimer disease
Relevant information
Software
030217 neurology & neurosurgery
Research Paper
Information integration
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- RNA Biology
- Accession number :
- edsair.doi.dedup.....461046a605d4b2d677a84364fb0750ec