Back to Search
Start Over
Efficacy and tolerability of telaprevir for chronic hepatitis virus C genotype 1 infection: a meta-analysis
- Source :
- PLoS ONE, Vol 7, Iss 12, p e52158 (2012), PLoS ONE
- Publication Year :
- 2012
- Publisher :
- Public Library of Science (PLoS), 2012.
-
Abstract
- BackgroundChronic hepatitis C virus (HCV) infection is one of the leading causes of hepatic cirrhosis and hepatocellular carcinoma, and HCV genotype 1 is the most prevalent genotype and is resistant to current standard therapy. We performed this meta-analysis to evaluate the efficacy and safety of telaprevir-based therapy for chronic HCV genotype 1 infection.MethodsWe included randomized controlled trials with no year or language restriction. All data were analyzed using a random-effects model by Review Manager v5.0. The primary outcome was the proportion of patients achieving sustained virologic response (SVR), and the secondary outcomes were HCV relapse rate, incidence of severe adverse events (SAEs), and discontinuation due to adverse events.ResultsThe proportion of achieving SVR was significantly higher in the telaprevir group (odds ratio [OR] =3.40 [1.92, 6.00], PConclusionDespite its higher incidence of SAEs and discontinuation due to adverse events, telaprevir-based therapy can increase the proportion of achieving SVR in both previously treated and untreated chronic HCV-1 infected patients.
- Subjects :
- medicine.medical_specialty
Drugs and Devices
Genotype
Clinical Research Design
Gastroenterology and hepatology
Science
Alpha interferon
Viral diseases
Gastroenterology
Antiviral Agents
Telaprevir
Hepatitis
chemistry.chemical_compound
Adverse Reactions
Internal medicine
Ribavirin
medicine
Humans
Adverse effect
Liver diseases
Multidisciplinary
business.industry
Incidence (epidemiology)
Clinical Pharmacology
Interferon-alpha
Odds ratio
Hepatitis C, Chronic
Hepatitis C
Discontinuation
Infectious hepatitis
chemistry
Tolerability
Immunology
Infectious diseases
Medicine
Meta-Analyses
business
Oligopeptides
medicine.drug
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 7
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....46107aaa6fade81b1386807493a1a81b