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Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma

Authors :
Argyro Fourtouna
David Herrero-Martin
Stephan Niedan
Dave N. T. Aryee
Raphaela Schwentner
Lucia T. Riedmann
Source :
Sarcoma, Vol 2011 (2011), Sarcoma
Publication Year :
2011
Publisher :
Hindawi Limited, 2011.

Abstract

Ewing's sarcoma family tumors (ESFT) are characterized by specific chromosomal translocations, which give rise to EWS-ETS chimeric proteins. These aberrant transcription factors are the main pathogenic drivers of ESFT. Elucidation of the factors influencing EWS-ETS expression and/or activity will guide the development of novel therapeutic agents against this fatal disease.

Subjects

Subjects :
business.industry
Ewing's sarcoma
Chromosomal translocation
Review Article
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Bioinformatics
lcsh:RC254-282
Fusion protein
Ews fli1
Oncology
Cancer research
Medicine
Fatal disease
Radiology, Nuclear Medicine and imaging
Sarcoma
business
Transcription factor

Details

ISSN :
13691643 and 1357714X
Volume :
2011
Database :
OpenAIRE
Journal :
Sarcoma
Accession number :
edsair.doi.dedup.....461f7a906c044d29a7abb334f4dc8639

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