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Predictive Factors of Late-onset Rectal Mucosal Changes After Radiotherapy of Prostate Cancer
- Publication Year :
- 2017
- Publisher :
- International Institute of Anticancer Research, 2017.
-
Abstract
- Background/Aim: The Vienna Rectoscopy Score (VRS; from 0, absence of rectal mucosal changes, to 5) assessed 1 year after radiotherapy is a surrogate end-point of late rectal toxicity. The aim of this study was to investigate the association between treatment-related factors and 1-year VRS. Patients and Methods: We performed a retrospective analysis of prospectively collected data. Patients with prostate adenocarcinoma treated with definitive or postoperative radiotherapy (RT) underwent endoscopy 1 year after RT. Relationships between VRS of 2 or more and treatment parameters were investigated by univariate and multivariate logistic analyses. Results: One hundred and ninety-five patients (mean age=69 years; range=43-81 years) were considered eligible for the study. At univariate analysis, patients treated with hypofractionation plus radiosurgery boost (p
- Subjects :
- 0301 basic medicine
Oncology
Adult
Male
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
Urology
prostate cancer radiotherapy
General Biochemistry, Genetics and Molecular Biology
Vienna Rectoscopy Score
Radiosurgery
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Rectal toxicity
Internal medicine
medicine
radiation-induced GI toxicity
Humans
Risk factor
Intestinal Mucosa
Radiation Injuries
Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA
Aged
Retrospective Studies
Pharmacology
Aged, 80 and over
Univariate analysis
Radiotherapy
business.industry
Rectum
Prostatic Neoplasms
Radiotherapy Dosage
Odds ratio
Colonoscopy
Middle Aged
medicine.disease
Confidence interval
Radiation therapy
030104 developmental biology
030220 oncology & carcinogenesis
Radiotherapy, Intensity-Modulated
Radiotherapy, Conformal
business
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....4638a70f6f49accb8dec79b74054e020