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Neurobiology of Depression
- Source :
- Neuron. 34:13-25
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- Current treatments for depression are inadequate for many individuals, and progress in understanding the neurobiology of depression is slow. Several promising hypotheses of depression and antidepressant action have been formulated recently. These hypotheses are based largely on dysregulation of the hypothalamic-pituitary-adrenal axis and hippocampus and implicate corticotropin-releasing factor, glucocorticoids, brain-derived neurotrophic factor, and CREB. Recent work has looked beyond hippocampus to other brain areas that are also likely involved. For example, nucleus accumbens, amygdala, and certain hypothalamic nuclei are critical in regulating motivation, eating, sleeping, energy level, circadian rhythm, and responses to rewarding and aversive stimuli, which are all abnormal in depressed patients. A neurobiologic understanding of depression also requires identification of the genes that make individuals vulnerable or resistant to the syndrome. These advances will fundamentally improve the treatment and prevention of depression.
- Subjects :
- biology
Depression
Neuroscience(all)
General Neuroscience
Hippocampus
Nucleus accumbens
CREB
Amygdala
Disease Models, Animal
medicine.anatomical_structure
Neurobiology
Neurotrophic factors
medicine
biology.protein
Animals
Humans
Antidepressant
Aversive Stimulus
Psychology
Neuroscience
Depression (differential diagnoses)
Subjects
Details
- ISSN :
- 08966273
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Neuron
- Accession number :
- edsair.doi.dedup.....464d9f8bc71d31dfb3a0229eaf190f5d