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Inner retinal oxygen metabolism in the 50/10 oxygen-induced retinopathy model
- Source :
- Scientific Reports
- Publication Year :
- 2015
-
Abstract
- Retinopathy of prematurity (ROP) represents a major cause of childhood vision loss worldwide. The 50/10 oxygen-induced retinopathy (OIR) model mimics the findings of ROP, including peripheral vascular attenuation and neovascularization. The oxygen metabolism of the inner retina has not been previously explored in this model. Using visible-light optical coherence tomography (vis-OCT), we measured the oxygen saturation of hemoglobin and blood flow within inner retinal vessels, enabling us to compute the inner retinal oxygen delivery (irDO2) and metabolic rate of oxygen (irMRO2). We compared these measurements between age-matched room-air controls and rats with 50/10 OIR on postnatal day 18. To account for a 61% decrease in the irDO2 in the OIR group, we found an overall statistically significant decrease in retinal vascular density affecting the superficial and deep retinal vascular capillary networks in rats with OIR compared to controls. Furthermore, matching the reduced irDO2, we found a 59% decrease in irMRO2, which we correlated with a statistically significant reduction in retinal thickness in the OIR group, suggesting that the decreased irMRO2 was due to decreased neuronal oxygen utilization. By exploring these biological and metabolic changes in great detail, our study provides an improved understanding of the pathophysiology of OIR model.
- Subjects :
- medicine.medical_specialty
Apparent oxygen utilisation
chemistry.chemical_element
Biology
Oxygen
Retina
Article
Renal Circulation
Neovascularization
chemistry.chemical_compound
Ophthalmology
medicine
Animals
Retinopathy of Prematurity
Oxygen saturation (medicine)
Multidisciplinary
Neovascularization, Pathologic
Retinal Vessels
Retinopathy of prematurity
Retinal
Anatomy
medicine.disease
eye diseases
Rats
Disease Models, Animal
medicine.anatomical_structure
chemistry
sense organs
medicine.symptom
Blood Flow Velocity
Tomography, Optical Coherence
Retinopathy
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Scientific reports
- Accession number :
- edsair.doi.dedup.....467d95c85403817dffc8248a322cf03c